A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.

Suspected acute infection/sepsis patients Patients eligible for inclusion are required to fulfill all of the following criteria: * Written informed consent must be obtained from the patient or his/her legal guardian. * Over 18 years of age * Clinical suspicion of acute infection/sepsis as defined by the attending physician, based on clinical presentation. Healthy individuals Patients eligible for inclusion are required to fulfill all of the following criteria: * Written informed consent must be obtained from the patient * Over 18 years of age * No clinical suspicion of acute infection. Exclusion Criteria: Suspected acute infection/sepsis patients Patients fulfilling the following criteria are not eligible for inclusion in this study: * HIV, HBV, active HCV or active Tuberculosis infection (self-declared or known from medical records). * Pregnancy- self reported or medically confirmed. Healthy individuals Patients fulfilling the following criteria are not eligible for inclusion in this study: * Episode of infection in the last 2 weeks * Major trauma and\\or burns and\\or surgery in the last 2 weeks * HIV, HBV, active HCV or active Tuberculosis infection (self-declared or known from medical records) * Elective surgery patients * Pregnancy- self reported or medically confirmed