The goal of this clinical trial is to look at the effect tranexamic acid (TXA) may have on reducing bruising, swelling, and pain after facial filler injection. The main question it aims to answer is: * Does the addition of TXA to hyaluronic acid (HA) reduce bruising, swelling, and tenderness after HA injection? Participants will receive the study medication along with the standard facial filler injection and complete surveys.
The overall purpose of this study is to evaluate the safety and efficacy of co-administration of TXA with HA in reducing swelling, bruising and pain after facial injection. Researchers will do this by comparing HA to HA+TXA in participants undergoing facial filler injections. Participants undergoing facial filler injections almost always have the same type of injection performed bilaterally in order to maintain symmetry. This provides a unique opportunity where participants can serve as their own controls. Therefore, researchers have designed this as a half face study. Participants will be injected with HA on half of their face and the other half of the face will be injected with HA+TXA. Researchers will then assess swelling, bruising, pain, and overall satisfaction using participant self-reported surveys, physician surveys, and review of medical records.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
40
University of Wisconsin - Madison
Madison, Wisconsin, United States
RECRUITINGIntensity of bruising on TXA + HA half of face
Participants will score the intensity of bruising on a 5-point Likert scale, where 1 = no bruising and 5 = severe bruising.
Time frame: Post-procedure day 7
Intensity of bruising on saline + HA half of face
Participants will score the intensity of bruising on a 5-point Likert scale, where 1 = no bruising and 5 = severe bruising.
Time frame: Post-procedure day 7
Duration of bruising on TXA + HA half of face
Participants will indicate on what day their bruising disappeared, or whether it is still there.
Time frame: Post-procedure day 7
Duration of bruising on saline + HA half of face
Participants will indicate on what day their bruising disappeared, or whether it is still there.
Time frame: Post-procedure day 7
Intensity of bruising on TXA + HA half of face
Participants will score the intensity of bruising on a 5-point Likert scale, where 1= no bruising and 5= severe bruising.
Time frame: Post-procedure day 1
Intensity of bruising on saline + HA half of face
Participants will score the intensity of bruising on a 5-point Likert scale, where 1= no bruising and 5= severe bruising.
Time frame: Post-procedure day 1
Duration of bruising on TXA + HA half of face
Participants will indicate on what day their bruising disappeared, or whether it is still there.
Time frame: Post-procedure day 1
Duration of bruising on saline + HA half of face
Participants will indicate on what day their bruising disappeared, or whether it is still there.
Time frame: Post-procedure day 1
Intensity of swelling on TXA + HA half of face
Participants will score the intensity of swelling on a 5-point Likert scale, where 1 = no swelling and 5 = severe swelling.
Time frame: Post-procedure days 1 and 7
Intensity of swelling on saline + HA half of face
Participants will score the intensity of swelling on a 5-point Likert scale, where 1 = no swelling and 5 = severe swelling.
Time frame: Post-procedure days 1 and 7
Intensity of pain on TXA + HA half of face
Participants will score the intensity of pain on a 10-point Likert scale, where 0 = no pain and 10 = worst pain possible.
Time frame: Post-procedure days 1 and 7
Intensity of pain on saline + HA half of face
Participants will score the intensity of pain on a 10-point Likert scale, where 0 = no pain and 10 = worst pain possible.
Time frame: Post-procedure days 1 and 7
Overall satisfaction with aesthetic of TXA + HA half of face
Participants will rate their overall satisfaction on a 5-point Likert scale where 1 = completely dissatisfied and 5 = completely satisfied
Time frame: Post-procedure days 1 and 7
Overall satisfaction with aesthetic of saline + HA half of face
Participants will rate their overall satisfaction on a 5-point Likert scale where 1 = completely dissatisfied and 5 = completely satisfied
Time frame: Post-procedure days 1 and 7
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