The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic

Mansoura University50 enrolled

Overview

The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal therapy. By elucidating the molecular mechanisms underlying the therapeutic effects of vitamin D, this research seeks to contribute to the development of more effective treatment strategies for periodontitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Periodontal Pocket

Interventions

vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel

Scaling and root debridement then inject gel in the pocket

vitamin D3 gel (regular non-nanoparticle form)DIETARY_SUPPLEMENT

Scaling and root debridement then inject gel in the pocket

Poly lactic-co-glycolic acid nanoparticles placebo gelOTHER

Scaling and root debridement then inject gel in the pocket

only mechanical debridementPROCEDURE

Scaling and root debridement

Eligibility

Sex: ALLMin age: 25 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with attachment loss 3-4 mm * periodontal pocket ≤ 5 mm Exclusion Criteria: * \- Patients with sensitivity to the medication used in the study. * Patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study. * Patients with systemic diseases. * Pregnant and lactating females. * Smokers and tobacco chewers. * Patients not compliant with oral hygiene procedures.

Locations (1)

Alaaeldin Ahmed Taha

Cairo, Egypt

Outcomes

Primary Outcomes

Periodontal Assessment

Periodontal Index

Time frame: 12 weeks

Secondary Outcomes

Interleukin 8

level of interleukin 8 in gingival crevicular fluid will be tested via elisa

Time frame: 8 weeks

alkaline phosphatase

level of alkaline phosphatase in gingival crevicular fluid will be tested via elisa

Time frame: 8 weeks

Data from ClinicalTrials.gov

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