This clinical research trial will evaluate the safety and tolerability of an experimental drug, ALN-F1202, in healthy participants. The purpose of this trial is to learn about how safe and tolerable the experimental drug is. The trial is looking at several other research questions, including: * What side effects may happen from taking the experimental drug? * How much experimental drug is in the blood at different times? * Whether the body makes antibodies against the experimental drug (which could make the drug less effective or could lead to side effects). * What is the best dose of the experimental drug?
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
56
Administered per the protocol
Administered per the protocol
Center for Clinical Pharmacology University Hospitals Leuven (UZ Leuven)
Leuven, Vlaams-Brabant, Belgium
Incidence of Treatment Emergent Adverse Events (TEAEs)
Time frame: Up to 190 Days
Severity of TEAEs
Time frame: Up to 190 Days
Change in activated Partial Thromboplastin Time (aPTT)
Time frame: Baseline up to 190 Days
Change in Prothrombin Time (PT)
Time frame: Baseline up to 190 Days
Concentration of combined ALN-F1202 and metabolites in plasma
Time frame: Up to 190 Days
Extent of urinary excretion of combined ALN-F1202 and metabolites
Time frame: Within 24 hours of treatment
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