Correlation of Blood Serum Renalase and Microcirculation Obstruction in Patients with Acute Myocardial Infarction After Primary Percutaneous Coronary Intervention

The Third Xiangya Hospital of Central South University200 enrolled

Overview

This research will explore the association between blood serum renalase and microcirculation obstruction in patients with acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PCI). The investigators aim to identify potential risk factors for microcirculation obstruction in AMI patients after PPCI.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Acute Myocardial Infarction

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age ≥ 18 years; 2. STEMI symptom onset time \< 12 hours; 3. STEMI symptom onset time 12-48 hours with persistent ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias; 4. High-risk NSTEMI; 5. Emergency PCI; 6. Voluntary informed consent. Exclusion Criteria: 1. Non-obstructive acute myocardial infarction; 2. Severe chronic kidney disease (defined as estimated glomerular filtration rate \< 20 mL/min per 1.73 m²); 3. Life expectancy \< 1 year; 4. Pregnant or planning to become pregnant; 5. Emergency PCI failure.

Locations (1)

The Third Xiangya Hospital of Central South University

Changsha, Hunan, China

Outcomes

Primary Outcomes

Number of Participants with Microvascular Obstruction Assessed by Contrast-Enhanced Magnetic Resonance Imaging 3-7 Days After Percutaneous Coronary Intervention.

Microvascular obstruction (MVO) was qualitatively recognized as a subendocardial lack of enhancement at first-pass perfusion (FPP) sequences and as a hypointense region within the hyperintense infarcted area at early gadolinium enhancement (EGE) and late gadolinium enhancement (LGE) sequences.

Time frame: 3-7 days after PPCI