HIV and Multi-Drug Resistant Tuberculosis: a Study on Clinical Outcomes

Zahedan University of Medical Sciences222,128 enrolled

Overview

This study aims to investigate the relationship between HIV infection and multi-drug resistant tuberculosis (MDR-TB) among affected individuals in Zahedan, Iran. It will involve a detailed analysis of patient demographics, clinical characteristics, and treatment outcomes to enhance understanding of this co-infection. The findings may inform better treatment strategies and healthcare policies for managing these diseases in similar populations.

Study Type

OBSERVATIONAL

Enrollment

222,128

Conditions

HIV Infection MDR-TB

Interventions

Examination of HIV Infection in Patients with Multi-Drug Resistant Tuberculosis (MDR-TB)OTHER

This meta-analysis examines the impact of HIV infection on the prevalence and outcomes of multi-drug resistant tuberculosis (MDR-TB) among affected populations. The analysis synthesizes data from multiple studies conducted across various countries, focusing on the correlation between HIV co-infection and MDR-TB rates, treatment outcomes, and demographic factors. The findings aim to enhance understanding of the complex interactions between HIV and MDR-TB, ultimately informing clinical practices and public health strategies.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults (aged 18 years and older) diagnosed with both HIV and multi-drug-resistant tuberculosis (MDR-TB). * Studies published in peer-reviewed journals. * Studies that provide data on the co-occurrence of HIV and MDR-TB. * Participants from diverse geographical regions to enhance generalizability. * Studies with clear definitions of MDR-TB according to WHO guidelines. Exclusion Criteria: * Studies that focus solely on drug-susceptible tuberculosis without MDR-TB. * Studies involving pediatric populations (under 18 years of age). * Non-original research such as reviews, editorials, and commentaries. * Studies lacking sufficient data on the co-occurrence of HIV and MDR-TB. * Studies that do not adhere to ethical guidelines for human subjects or lack appropriate ethical approvals.

Locations (1)

Zahedan University of Medical Sciences

Zahedan, Sistan and Baluchestan, Iran

Outcomes

Primary Outcomes

Prevalence of Multi-Drug Resistant Tuberculosis (MDR-TB) in HIV-Positive Patients

This study aims to determine the prevalence of multi-drug resistant tuberculosis (MDR-TB) among patients co-infected with HIV. Data will be collected from various studies included in the meta-analysis, focusing on the incidence rates of MDR-TB in this population. The analysis will provide insights into the challenges faced in treating HIV-positive individuals with MDR-TB and highlight the need for targeted interventions.

Time frame: Data collected over the course of the studies from 2006 to 2018.

Data from ClinicalTrials.gov

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