A Clinical Trial to Evaluate the Safety and Tolerability of TQB3911 Tablets in Patients With BCR::ABL Fusion Gene Positive Leukemia

Inclusion Criteria: * The subjects voluntarily joined the study, signed the informed consent, and had good compliance; * Age: ≥18 years old (when signing the informed consent); Eastern Cooperative Oncology Group Performance Status (ECOG PS) score: 0-2; Expected survival of more than 3 months; * During the screening period, the patients were identified as Chronic myelogenous leukemia-Chronic phase (CML-CP) or accelerated phase (AP) patients by bone marrow cell morphological examination, molecular biological examination or cytogenetic examination; * Chronic myelogenous leukemia (CML) patients who are intolerant to Tyrosine kinase inhibitors (TKI) drugs or whose therapeutic effect is not satisfactory (that is, the therapeutic response evaluation result is failure) * The main organs function well * Female subjects of reproductive age should agree to use contraceptives (such as Iuds, contraceptives, or condoms) during the study period and for 6 months after the end of the study; Have a negative serum pregnancy test within 7 days prior to study enrollment and must be a non-lactating subject; Male subjects should agree to use avoidance during the study period and for 6 months after the end of the study period. Exclusion Criteria: * Had or was currently suffering from other malignant tumors within 5 years before the first medication * Combined with active central nervous system leukemia * Major surgical treatment and significant traumatic injury were received within 28 days before the start of study treatment * Previous history of myocardial infarction, pulmonary hypertension, or angina pectoris within 3 months before the first medication, or clinically significant arrhythmias such as ventricular tachycardia, complete left bundle branch block, and high atrioventricular block * Acute pancreatitis and a history of chronic pancreatitis within 12 months before the first medication * History of interstitial lung disease, radiation pneumonia requiring steroid treatment, or drug-related pneumonia * Patients with CML-CP who have achieved complete cytogenetic response (CCyR) * Received live attenuated vaccine within 4 weeks before the first dose, or planned to receive live attenuated vaccine during study participation * Use of drugs that may have caused QT prolongation or tip torsical tachycardia in the 7 days prior to initial administration, or continuation of these medications during the study period