Patients will be asked to visit the study center 2 times, the first time for clinical assessment and a second time for sample collection. Healthy controls will only be asked to visit the study center for sample collection. A sample of blood and saliva will be collected in order to measure CGRP levels and DNA and hormone testing.
CGRP is a neuropeptide related to migraine pathophysiology, which can be found in human saliva in both patients and healthy controls. The differences in CGRP levels may help us explain the differences in the treatment response. A sample of saliva will be collected in order to measure CGRP levels and a blood sample will be collected in order to conduct a DNA test and hormones test.
Study Type
OBSERVATIONAL
Enrollment
440
Sampling of CGRP in saliva and DNA blood test and sex hormones blood test.
Vall d'Hebron University Hospital
Barcelona, Barcelona, Spain
RECRUITINGCGRP level
Measure of CGRP in saliva
Time frame: Through study completion, an average of 1 year
Hormone levels
Blood test to quantify female hormones (FSH, LH, estradiol, progesterone, prolactin) and male hormones (testosterone) in all participants except for prepubertal children.
Time frame: Through study completion, an average of 1 year
DNA test
DNA testing for CGRP or its receptor related genes (CALCA, CALCB, CALCRL and RAMP1)
Time frame: Through study completion, an average of 1 year
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