Developmental Trajectory of Gene and Life Participation in Children With Developmental Delay

Chang Gung Memorial Hospital500 enrolled

Overview

The goal of this observational study is to learn the factors affecting the quality of life in children's development. The main hypothesis for this study is: If the level of well-being increases in age, could the quality of life be enhanced in terms of function and participation? Participant will be given assessment every year for five years in total. No intervention will be given during the whole study period.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Genetics Life Participation

Eligibility

Sex: ALLMin age: 6 YearsMax age: 15 Years

Medical Language ↔ Plain English

Normal developing children Inclusion Criteria: * Agreeing in consent * In the age range of 6-15 years old Exclusion Criteria: * Diseases of Central Nervous System * Diseases of Neuromuscular * Nature deficit disorder * Genetic Disorder * Sensory Integration disorder * Auditory disorder Development delay children Inclusion Criteria: * Agreeing in consent * In the age range of 6-15 years old * Diagnosed of Developmental Delay Exclusion Criteria: * Diseases of Central Nervous System * Diseases of Neuromuscular * Nature deficit disorder * Genetic Disorder * Sensory Integration disorder * Auditory disorder

Locations (1)

Chang Gung Memorial Hospital

Taoyuan, Taiwan

Outcomes

Primary Outcomes

Score of participation (< 3y)

Children Assessment of Participation and Enjoyment and Preferences for Activity of Children (Higher scores means a better outcome.)

Time frame: baseline

Score of participation (3y > 15y)

Pediatric Quality of Life Inventory TM (Scores from 0 to 102, higher scores mean a better outcome.)

Time frame: Baseline

Secondary Outcomes

Gene Test

Whole-Exome Sequencing (Use Burrows-Wheeler Aligner (BWA) 85, Samtools86, Picard, Genome Analysis Toolkit (GATK) to screen out the variant discovery and genotyping.)

Time frame: Baseline

Data from ClinicalTrials.gov

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