NPA-OSA Device Tolerability, Usability and Acclimation Clinical Study in Adult Obstructive Sleep Apnea (OSA) Patients

Inclusion Criteria: * Capacity and willingness to sign consent * Patient willingness to commit to and complete study over a 30-day time period * Confirmed diagnosis of moderate to severe OSA (AHI \>= 15) * OSA caused by upper airway obstruction * CPAP non-compliant where CPAP compliance is defined as using CPAP for at least 4 hours a night for at least 70% of nights or interest in an alternative sleep apnea therapy * Adequate manual dexterity to demonstrate ability to self-insert and remove device Exclusion Criteria: * Within 3 months of initiating CPAP use, and actively using CPAP * Supraglottic airway collapse * Distal airway stenosis * Tracheobronchomalacia * Currently pregnant * Active COVID-19 infection * Need for anticoagulative therapy * Severe nasal allergies * Bleeding disorder * More than mild elevation of End-tidal carbon dioxide (ETCO2) or total carbon dioxide (TCO2) values \>60 mmHg for \>10% of sleep time * Restrictive thoracic disorders * Silicone, lidocaine, neosynephrine allergy * Recurrent epistaxis * Uncontrolled or serious illness, included but not limited to: severe breathing disorders including hypercapnic respiratory failure, respiratory muscle weakness, bullous lung disease (as seen in some types of emphysema), bypassed upper airway, pneumothorax, pneumomediastinum, etc.; severe heart disease (including heart failure); or pathologically low blood pressure