Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: a Relation to Periodontal Inflammaging

Inclusion Criteria: 1. Male or Female 2. Aged below 40 or above 60. 3. Have at least 16 natural teeth excluding wisdom. 4. Provide informed consent and willingness to cooperate with study protocol. 5. Periodontitis stage II patients (23): * CAL from 3-4 mm. * Radiographic bone loss (15% to 33%). * No tooth loss due to periodontitis. * Maximum probing depth ≤ 5 mm, mostly horizontal bone loss Exclusion Criteria: * 1- Patients with any smoking habits 2- History of antibiotics in the previous three months. 3- Pregnant or lactating female. 4- Treatment with any systemic drug. 5- History of systemic disease. 6- Patients who received periodontal treatment in the last 6 months