Alteration of Sweet Taste Perception After Reduction of Sweet Food and Beverage Consumption.

N/AEnrolling By InvitationNCT06678386

Mahidol University58 enrolled

Overview

The goal of this clinical trial is to determine whether reducing sugar intake by 50% for 12 weeks can change sweet taste perception in healthy adults and its consequences. The main questions it aims to answer are: * Does sweet intensity change after reducing daily sugar intake by 50% for 12 weeks? * How does sweet intensity change after completing dietary modification for 8 weeks? * Does individual daily sugar intake change after completing dietary modification for 8 weeks? Researchers will compare reducing daily sugar intake by 50% for 12 weeks to an unmodified diet to see if sugar reduction can change sweet intensity. Participants will: * Reduce daily sugar intake by 50% or maintain an unmodified diet for 12 weeks. * Visit the clinic three times for anthropometric measurements, sweet perception tests, and to complete questionnaires. * Keep a diet record for a total of 15 days during the research period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Health-Related Behavior

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 59 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * People with a fasting blood sugar level below 126 mg/dL or an HbA1C below 6.5% in the past 6 months, who are not currently being treated for diabetes. * People who score 10 or more points on the sweet food consumption behavior questionnaire. * People who are able to communicate in the Thai language. * People who are able to chat and use video calls via the Line application. * People who agree to modify their diet and beverages according to the recommendations of a dietitian. * People who agree to undergo sweet taste testing, complete a food record, and fill out a questionnaire. Exclusion Criteria: * People with uncontrolled chronic conditions who have had changes in their treatment within the past 3 months. * People with a history of severe illness in the past 6 months. * People who regularly use medication, excluding contraceptives and vitamins. * Pregnant women. * People who have experienced a weight change of at least 10% over the past 3 months.

Outcomes

Primary Outcomes

Sweet intensity change from baseline after 12 weeks of the intervention.

Percentage of participants whose sweet intensity has increased after reducing daily sugar intake by 50% for 12 weeks, compared to those with an unmodified diet.

Time frame: 16 weeks from baseline (12 weeks after the start of the intervention)

Secondary Outcomes

Sweet intensity change from baseline after completing the intervention for 8 weeks.

Percentage of participants whose sweet intensity increased after completing dietary modification for 8 weeks, compared to those with an unmodified diet.

Time frame: 24 weeks from baseline

Changes in sugar consumption behavior from baseline

The average daily caloric intake from sugars after completing dietary modification for 8 weeks, compared to before the dietary change.