The purpose of this study is to learn about lorlatinib for the possible treatment of lung cancer which could not be controlled. This study is seeking participants who: * have lung cancer that could not be controlled. * have a type of gene called a ROS proto-oncogene 1. A gene is a part of your DNA that has instructions for making things your body needs to work. * have received at least 1 treatment before. All participants in this study had received lorlatinib. Lorlatinib is a tablet that is taken by mouth at home. They continued to take lorlatinib until their cancer was no longer responding. The study will look at the experiences of people receiving the study medicine. This will help to see if the study medicine is safe and effective.
Study Type
OBSERVATIONAL
Enrollment
35
Lorlatinib is an ALK/ROS1 tyrosin kinase inhibitor.
Pfizer Inc
Taipei, Taiwan
real-world progression-free survival
Time to real-world disease progression or death, whichever occurs first, during observation period from index date will be summarized by the K-M plot with the corresponding 95% CI. Index date is the date of the first dose of lorlatinib.
Time frame: 74 months from 1st April, 2018
The overall survival (OS)
Time to death during observation period from index date will be summarized by the K-M plot with the corresponding 95% CI. Index date is the date of the first dose of lorlatinib.
Time frame: 74 months from 1st April, 2018
The real world time to next treatment (rwTTNT)
Time to subsequent treatment or death, whichever occurs first, during observation period from index date will be summarized by the K-M plot with the corresponding 95% CI. Index date is the date of the first dose of lorlatinib.
Time frame: 74 months from 1st April, 2018
The real world intracranial progression free survival (rwICPFS)
Time to real-world intracranial disease progression or death, whichever occurs first, during observation period from index date will be summarized by the K-M plot with the corresponding 95% CI. Index date is the date of the first dose of lorlatinib.
Time frame: 74 months from 1st April, 2018
Number and proportion of patients receiving each regimen of systemic anti-cancer therapy
The percentage of patients with each systemic anticancer therapy for lung cancer.
Time frame: 74 months from 1st April, 2018
Mean (SD), median (interquartile range, IQR), minimum and maximum value of duration of therapy (DoT) of lorlatinib
Time to real-world discontinuation of lorlatinib or death, whichever occurs first, during observation period from index date will be summarized by the K-M plot with the corresponding 95% CI. Index date is the date of the first dose of lorlatinib.
Time frame: 74 months from 1st April, 2018
Number and proportion of patients receiving concomitant antihyperlipidemic agents
The number and percentage of patients receiving antihyperlipidemic agents received along with lorlatinib during the same treatment period
Time frame: 74 months from index date; index date is the date of the first dose of lorlatinib
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