Phase I Clinical Trial of PCV24 in People Aged 18 Years and Older

Inclusion Criteria: 1. Volunteers over the age of 18 on the day of screening, and can provide legal identification; 2. Informed consent must be obtained from the volunteer and signed informed consent form; 3. Volunteers are able and willing to comply with the requirements of the clinical trial protocol and can attend all visits; 4. Armpit body temperature ≤ 37.0 °C on the day of enrollment. Exclusion Criteria: 1. Previous pneumococcal vaccination, or history of invasive disease caused by pneumococcal in the past; 2. Have any previous history of severe allergies to vaccines or drugs, such as anaphylactic shock, allergic laryngeal edema, Henoch-Schonlein purpura, thrombocytopenic purpura, local allergic necrosis reaction (Athus reaction), etc.; 3. Have been diagnosed with congenital or acquired immunodeficiency, or have recently received immunosuppressant therapy, such as systemic glucocorticoid therapy such as prednisone or similar drugs \> 5 mg/day for more than 2 consecutive weeks in 1 month before vaccination (Note: the use of topical and inhaled/nebulized steroids can participate); 4. Suffering from serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension that cannot be controlled by medication (when measured on site: systolic blood pressure ≥ 160 mmHg, diastolic blood pressure ≥100 mmHg), etc.; 5. Suffering from acute febrile illness or infectious diseases, such as tuberculosis, viral hepatitis, etc.; 6. History of nervous system damage, severe congenital malformations, severe developmental disabilities, severe genetic defects, severe malnutrition, etc.; 7. Have a history or family history of epilepsy, encephalopathy, or psychiatric disorders; 8. Those who have been diagnosed with thrombocytopenia, any abnormal coagulation function (such as coagulation factor deficiency, coagulation disorders, platelet abnormalities, etc.) or contraindications to intramuscular injection such as anticoagulant therapy; 9. asplenia, functional asplenia, and asplenia or splenectomy due to any cause; 10. Suffering from severe chronic diseases or conditions that cannot be controlled smoothly in the advanced stage, such as diabetes, thyroid disease, etc.; 11. Have received blood or blood-related products or immunoglobulins within 3 months; 12. Received live attenuated vaccine within 14 days; 13. Received other vaccines within 7 days; 14. Received other investigational drugs or vaccines within 1 month; 15. Is participating in or plans to participate in clinical studies of other drugs or vaccines during the study period; 16. Any other condition that, in the opinion of the investigator, may interfere with the study evaluation; 17. Those who have abnormal laboratory tests such as blood routine, blood biochemistry, and urine routine that are clinically significant and cannot be enrolled according to the comprehensive judgment of the investigator; 18. Exclusion Criteria for Partial Populations: Females of childbearing potential (18\~49 years old): positive urine pregnancy test on the day of enrollment, lactation, or pregnancy plans within 6 months.