The investigators hypothesis that PENG block will produce effective opioid sparing analgesia with enhanced motor recovery more than AQLB in elderly patients undergoing total hip replacement surgeries
Aim of the work: The aim of this study is to compare analgesic efficacy and motor recovery of the ultrasound guided anterior quadratus lumborum block and the pericapsular nerve group block Statistical Analysis: Data will be coded and entered using the statistical package SPSS version 22. Categorical data will be expressed frequency and proportion and will be compared by Chi2. Numerical data will be summarized using mean and standard deviation. Comparisons between groups for normally distributed data will be done using analysis of variance (ANOVA), while for non-normally distributed numeric variable will be done by Krauskal Wallis test. P value less than or equal to 0.05 will be considered statistically significant. All test will be two tailed
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
93
AQLB performed in the lateral position. A low-frequency convex probe for the abdomen (2-5) MHz convex probe, (Siemens ACUSON X300 Ultrasound System) was placed horizontally above the iliac crest. On ultrasound, The psoas major was located on the ventral side of the transverse process, the erector spinae was located on the dorsal side of the transverse process, and the quadratus lumborum was located on the lateral side of the transverse process. A 38-mm 22-gauge regional block needle was advanced in-plane from posterior to anterior directing the needle tip in the fascial plane between the psoas major and the quadratus lumborum that was confirmed by injecting 1 ml saline and watchingt the fluil fting the muscle while not distending any of the two muscles (hydro-localization). Then 30mL of local anaesthetic (29ml of 0.25% bupivacaine + 1 ml of dexamethasone (4mgs) was injected with observation of local anaesthesia spread in the fascial plane.
With the patients in supine position, A low-frequency convex probe (2-5 MHz) in was placed in a transverse plane over the anterior inferior iliac spine and then it was rotated 45 degrees in counter-clockwise direction to be aligned with the pubic ramus. In this view, the ilio-pubic eminence, iliopsoas muscle tendon, femoral nerve and vessels was observed. With in-plane approach, a 38-mm 22-gauge (22-G, 50-mm) regional block needle inserted in-plane, from lateral to medial to place the needle tip underneath the iliopsoas tendon, exactly between the ilipsoas fascia anteriorly and the pubic ramus posteriorly. Following negative resistance and aspiration tests, correct location of the needle tip was confirmed by injecting 1 ml saline. Then, 30mL of local anaesthetic (29ml of 0.25% bupivacaine+ 1ml of dexamethasone (4mgs) was injected while observing for adequate fluid spread.
Faculty of Medicine, Cairo University
Cairo, Egypt
The Total Amount of Morphine Consumption
Total dose of IV morphine (mg) administered as rescue analgesia during the first 24 postoperative hours. Morphine 0.05 mg/kg IV boluses were given when NRS ≥4, up to a maximum of 0.3 mg/kg/24 h. Reported as median (IQR).
Time frame: Immediatly post operative for 24 hours
Numeric Pain Rating Scale at Rest Over First 24 Hours
Pain intensity at rest using 0-10 Numeric Pain Rating Scale (0 = no pain, 10 = worst imaginable pain) measured at specified time points; data reported as median (IQR).
Time frame: 30 minutes, 2, 4, 6, 8, 12, 18, and 24 hours after surgery
Numeric Pain Rating Scale During Passive 90° Hip Flexion Over First 24 Hours
Pain intensity during passive 90° hip flexion using 0-10 NRS at same time points; reported as median (IQR).
Time frame: at 30 minutes, 2, 4, 6, 8, 12, 18 and 24 hours postoperatively
Time to First Rescue Morphine Analgesia
Time from arrival in PACU to first administration of IV morphine rescue dose (NRS ≥4). Reported as median (IQR).
Time frame: Immediatly post operative for 24 hours
Manual Muscle Test (MMT) Score for Quadriceps/Iliopsoas Over First 24 Hours
Manual muscle test (0-5 scale; 0 = no contraction, 5 = full ROM against gravity and maximal resistance) for quadriceps and iliopsoas muscles on the operated side, after extubation, at predefined time points.
Time frame: 30 minutes, 2, 4, 6, 8, 12, 18 and 24 hours postoperatively
Active Hip Flexion Range of Motion (0°-90°) Over First 24 Hours
Active hip flexion range of motion (degrees) of the operated hip, from 0° to 90°, assessed at same time points as MMTe. Reported as median (IQR).
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Pataints received opioid analgesia with genaral anesthesia
Time frame: 30 minutes, 2, 4, 6, 8, 12, 18 and 24 hours postoperatively
Total Intraoperative Fentanyl Dose
Total dose of IV fentanyl administered intraoperatively. Additional boluses of 1 μg/kg were given if MAP or HR increased by \>20% above baseline. Reported as mean ± SD.
Time frame: During surgery
Time to First Walk
Time from end of surgery to first ambulation (≥3 steps with walker). Reported as median (IQR)
Time frame: From end of surgery until first walk (within postoperative 24 h)
Length of Hospital Stay
Time from surgery to hospital discharge. Reported as mean ± SD.
Time frame: From date of surgery until discharge