Intrahepatic cholestasis of pregnancy is a liver condition in late pregnancy, causing itching and high bile acid levels that return to normal after birth. Babies born to mothers with this condition may have a higher risk of breathing issues. Researchers suspect bile acids might lead to a specific type of lung problem in newborns, but more studies are needed to confirm this.
Intrahepatic cholestasis of pregnancy is a hepatic complication that predominantly arises during the second or third trimester. It is characterized by serum bile acid levels above 10 micromol/L and persistent pruritus, which resolves after delivery. To date, it has been observed that respiratory distress syndrome occurs more frequently in neonates born to mothers with cholestasis of pregnancy, and a potential new entity, 'acute bile acid-induced pneumonia,' has been proposed, though statistical confirmation is lacking. Therefore, the investigators deem it imperative to conduct a study in the neonatal population to establish a definitive conclusion regarding neonatal pulmonary impairment secondary to maternal bile acid accumulation.
Study Type
OBSERVATIONAL
Enrollment
120
Clinical Hospital of Obstetrics and Gynecology "Prof. Dr. Panait Sârbu"
Bucharest, Bucharest, Romania
Biomarkers of epithelial injury
This trial wishes to evaluate if neonates born to mothers with intrahepatic cholestasis of pregnancy are prone to develop a more extensive epithelial injury compared to those of similar gestational age/birthweight/sex born to mothers with no liver disease.
Time frame: In the first 24 hours, at 2-3 days and at 7 days of life
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