FeNO Observation Study in ICU Patients With ARS

Shanghai Zhongshan Hospital1,000 enrolled

Overview

1. Main Objective: To compare the concentration of exhaled nitric oxide in patients with different severity of respiratory failure in ICU. 2. Secondary Purpose: 1. To observe the change of nitric oxide concentration in exhaled breath of patients with mechanical ventilation over time; 2. The relationship and differences between pulmonary ventilation blood flow levels in patients with different exhaled NO concentrations; 3. Reactivity of patients with different exhaled NO concentrations to inhaled nitric oxide therapy and the relationship between them.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Compare the Concentration of Exhaled Nitric Oxide in Patients With Different Severity of RF

Interventions

FeNO ObservationOTHER

FeNO was observed and measured among patients with advanced respiratory support

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: 1. Adult patients (≥18 years of age) with mechanical ventilation or advanced respiratory support in the ICU, regardless of gender; 2. The expected mechanical ventilation time of tracheal intubation is more than 24 hours; 3. The initial ventilator Settings of clinical routine were adopted: oxygen fraction (FIO2) = 50%, respiratory rate = 15/min, positive end-expiratory pressure (PEEP) = 5 cmH2O, tidal volume = 6-8 ml/kg ideal body weight (IBW), inspiration-exhalation ratio =1:2; 4. Agree to participate in this experiment and sign the informed consent. Exclusion Criteria: * 1.Use of any NO-containing drugs (such as nitroglycerin), anti-inflammatory drugs, or drugs or means that affect the airway diameter within 6 hours before the first FeNO measurement; 2. Participating in other clinical research projects; 3. Patients deemed unsuitable by the investigators.

Outcomes

Primary Outcomes

FeNO concentration

Exhaled nitric oxide concentration of patients with different severity of respiratory failure in ICU

Time frame: 1.5 year