the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
125
participants in this study will provide breath samples for carbon monoxide measurements pre and post liver resection
Englewood Hospital
Englewood, New Jersey, United States
RECRUITINGcorrelation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration
patients will be asked to donate exhaled breath into a smokerlyzer device
Time frame: measurements will be taken pre, then 4 hours and 24 hours post resection
level of carbon monoxide in exhaled air of patients
patients will be asked to donate exhaled breath into a smokerlyzer device
Time frame: measurements will be taken pre, then 4 hours and 24 hours post resection
quantity of liver regeneration, liver volume (ml)
CT liver volumetric studies
Time frame: one and three months after resection
quality of hepatic regeneration, normalized liver function
serum protein, albumin, AST and ALT, alkaline phosphatase, and bilirubin level
Time frame: one and three months post resection
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