Registration Trial of the Drug-coated Balloon for the Symptomatic Cerebral Atherosclerotic Stenosis

Incsion Criteria: * Age 18 to 80 years old at informed consent signing. * Symptomatic atherosclerotic stenosis of cerebrovascular arteries with ≥70% stenosis. * Medication ineffective. * modified Rankin Scale(mRS) score≤2. * The subject or guardian is able to understand the purpose of the study, is willing to participate and has given written informed consent. Exclusion Criteria: * History of acute ischemic stroke within 2 weeks; * Stenosis due to non-atherosclerotic lesions such as arterial dissection, Moya-Moya disease and vasculitic disease; * Target vessels complete occlusion or with thrombus in target vessels; * Target vessel with severe calcification or distortion that making interventional device is difficult to place; * History of stenting in the target artery; * Target vessel restenosis following stenting or balloon angioplasty; * Combined with other lesion with ≥70% stenosis in target vessel. * Residual stenosis ≥50% or vessel dissection with obvious blood flow restriction occurs after predilation. * Combined with intracranial tumour, arteriovenous malformation or aneurysm of the target vessel. * History of intracranial hemorrhage within 90days. * Presence of severe systemic diseases that cannot tolerate surgery, such as severe liver and kidney dysfunction; * Contraindication to the use of anticoagulants and antiplatelet agents, such as sllergy to anticoagulants and antiplatelet agents, active bleeding or coagulation disorders; * Allergic to contrast agents or rapamycin; * Pregnant or lactating women; * Participating or intending to participate in any other drug/device clinical trials; * Life expectancy \<1 year; * Any other conditions that the investigator deems the patient unsuitable for enrollment.