A Multicenter, Single-arm, Open-label Study Evaluating the Safety and Efficacy of AK112 Combined With Chemotherapy as First-line Treatment for Non-squamous NSCLC Patients With BRAIN Metastases and Negative Driver Genes (IVO BRAIN)

Inclusion Criteria: 1. The subjects voluntarily participated in the clinical study and had not received any systemic anti-tumor treatment (including any chemotherapy, targeted therapy, immunotherapy, etc.) 2. Male or female subjects aged 18-75 years (including the cutoff) at the time of signing the ICF 3. patients with histopathologically or cytologically confirmed stage IV non-squamous non-small cell lung cancer (nsqNSCLC) with brain metastases 4. Patients were required to provide a genetic testing report that showed negative driver genes, i.e., no EFGR sensitive gene mutation, no ALK or ROS1 gene fusion, no BRAF V600E sensitive gene mutation, and no RET gene fusion 5\. If not, qualified tumor tissue or blood should be provided for genetic testing. 5) MRI confirmed brain parenchymal metastasis, with ≥3 brain lesions 6: Or patients with 1-2 brain lesions who are not suitable for local treatment or refuse local treatment. At least one measurable brain lesion had to be at least 5mm in diameter. 6) For asymptomatic brain metastases or those with controlled intracranial hypertension after treatment with dehydration, medication could be continued at enrollment or during the study to maintain symptom stability 7\) At least one measurable target lesion as assessed by investigator according to RECIST v1.1 within 4 weeks before the first dose 8\) ECOG PS score of 0-1 9\) predicted survival time ≥12 weeks 10\) good vital organ function 11\) Female subjects must have a negative serum pregnancy test within 3 days before treatment, agree to use effective contraception during and after treatment for 6 months, and refrain from breastfeeding during treatment 12: Male patients provided consent to use contraception during treatment. Exclusion Criteria:1) known history of severe allergy to any monoclonal antibody (NCI-CTCAE 5.0 \> 3) Or known hypersensitivity to carboplatin/pemetrexed components 2: any active infection requiring systemic anti-infective therapy within 14 days before the first dose 3\) myocardial infarction with uncontrolled arrhythmia (including QTc interval ≥450 ms in men and ≥470 ms in women) within 6 months before the first dose (QTc interval was calculated with Fridericia's formula) 4: Or grade III-IV cardiac dysfunction according to the New York Heart Association (NYHA) standard or left ventricular ejection fraction \<50% by echocardiography 5\) subjects with ≥ grade 2 CTCAE peripheral neuropathy 6\) subjects had uncontrolled or symptomatic hypercalcemia (\>1.5 mmol/L ionized calcium or calcium \>12 mg/dL or corrected serum calcium \>ULN) 7\) subjects with previous or screening history of interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonia, or severely impaired pulmonary function, which may interfere with the detection and treatment of suspected drug-related pulmonary toxicity according to the investigator's judgment 8\) untreated active hepatitis B subjects (HBsag-positive and HBV-DNA \> 1000 copies /mL (200 IU/mL) or higher than the lower limit of detection, whichever is higher) and, for those with hepatitis B, required to receive anti-HBV treatment for the duration of the study treatment 9: Active hepatitis C subjects (positive for HCV antibodies and HCV-RNA levels above the lower limit of detection) 10: Or patients with known active syphilis infection (excluding patients with positive heterologous antibody test, negative non-heterologous antibody test and inactive infection confirmed by clinical judgment) 11 Or a known history of human immunodeficiency virus (HIV) positivity or screening positive for HIV 12\) the subject has a known active or suspected autoimmune disease. Subjects who were in a stable state and did not require systemic immunosuppressive therapy were allowed to enroll. 13\) patients with other active malignant tumors within 5 years or at the same time. Localized tumors that had been cured for more than 5 years, such as skin basal cell carcinoma, skin squamous cell carcinoma, superficial bladder cancer, prostate cancer in situ, cervical cancer in situ, and breast cancer in situ, were eligible for inclusion. 14\) Recipients of a live or attenuated vaccine within 28 days before the first dose, or having a plan to receive such vaccine during the study period. However, inactivated virus vaccines for seasonal influenza are permitted 15\) radical radiotherapy or whole brain radiotherapy (WBRT) to the skull within 3 months before the first dose 16\) subjects with spinal cord compression that could not be cured by surgery and/or radiotherapy 17\) patients with deep vein thrombosis, current anticoagulant or platelet therapy, or previous use of antiangiogenic drugs for deep vein thrombosis or severe bleeding 18\) poorly controlled (poorly controlled defined as BP ≥160/100 MMHG despite optimal hypertension treatment) 19\) had undergone major surgery within 28 days before the first dose (major surgery was defined for this study as a procedure requiring at least 3 weeks of recovery before being able to undergo study treatment) 20\) who are participating in another clinical study, or who have participated in any other clinical trial (including drugs, devices, etc.) and received intervention within 3 months before screening or within 5 half-lives (whichever is longer) 21\) candidates for or prior recipients of organ or bone marrow transplantation 22\) subjects had a known history of psychotropic drug abuse or drug use 23\) subjects with any factors considered by the investigator to be ineligible for the trial. \-