Evaluate early postoperative complications after surgery in Trendelenburg position with increased intraabdominal pressure (surgery with pneumoperitoneum). Evaluate the relationship between hemodynamic and metabolic changes on perioperative outcome.
Study Type
OBSERVATIONAL
Enrollment
100
Laparoscopic surgery (with controlled pneumoperitoneum) in the Trendelenburg position
Hadassah Medical Center
Jerusalem, Yerushalaim, Israel
RECRUITINGPerioperative change in urine NGAL
Measurement of the concentration of neutrophil gelatinase-associated lipocalin (as an early marker of kidney injury) in a urine sample taken from a Foley catheter
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery
Acute Kidney Injury
According to the KDIGO acute renal injury stage
Time frame: 2 hours after completion of surgery; 1 day after the procedure; 3 days after the procedure.
Perioperative change in serum NGAL
Measurement of the concentration of neutrophil gelatinase-associated lipocalin (as an early marker of kidney injury) in a blood sample
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery
Perioperatitve change in serum concentration of Cannabidiol
Measurement of the concentration of cannabidiol (as an early marker of kidney injury) in a blood sample
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery and 2h hours after completion of surgery
Perioperatitve change in urine concentration of Cannabidiol
Measurement of the concentration of cannabidiol (as an early marker of kidney injury) in a urine sample taken from a Foley catheter
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery
Perioperatitve change in TBW
Perioperative change in the bioimpedence-based measurement of Total Body Water (TBW)
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery
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Perioperatitve change in ECW
Perioperative change in the bioimpedence-based measurement of Extracellular Water (ECW)
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery
Perioperatitve change in serum pH
As measured by arterial blood gas
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery
Perioperatitve change in serum BE
Perioperatitve change in serum Base Excess (BE) As measured by arterial blood gas
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery
Perioperatitve change in serum lactate concentration
Perioperatitve change in serum lactate concentration as measured by arterial blood gas
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery
Perioperatitve change in serum syndecan-1 concentration
Measured by ELISA
Time frame: Baseline (after anesthesia induction but before beginning of surgery) and 2h hours after completion of surgery
Delirium
As assessed by CAM-ICU
Time frame: Within 7 days after surgery
CVA / TIA
New diagnosis of cerebrovascular accident or transient ischemic attack
Time frame: Within 30 days after surgery
Myocardial Ischemia
New myocardial ischemia, as diagnosed by ecg or serum troponin
Time frame: During hospital stay, within 30 days after surgery
Arrhythmia
New clinically significant arrhythmia
Time frame: During hospital stay, within 30 days after surgery
Atelectasis
New atelectasis
Time frame: During hospital stay, within 30 days after surgery
Pneumonia
According to CDC criteria
Time frame: During hospital stay, within 30 days after surgery
ARDS
New Acute Respiratory Distress Syndrome (ARDS) according to Berlin criteria
Time frame: During hospital stay, within 30 days after surgery