Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important tool for treating disease or recovering from exercise. The purpose of this research is to determine if a ketone drink can increase sugar uptake in our muscles. This research will provide new knowledge about the regulation of blood sugar.
Impaired skeletal muscle glucose uptake following a meal ("insulin resistance"), is a primary risk factor for developing type 2 diabetes. We and others have consistently shown that ingesting exogenous ketones can reduce blood glucose concentration. Mechanistically, this must arise through reduced glucose release (i.e. from liver), and/or increased uptake (i.e. into skeletal muscle). Our current MRC-funded work is focussing on ketone-liver interactions in patients with type 2 diabetes. Here we aim to investigate how KE influence skeletal muscle glucose metabolism.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
14
100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com) consumed 30 min prior to a mixed meal tolerance test
Placebo with bitter agent to flavour match, consumed 30 min prior to a mixed meal tolerance test
Nutritional Physiology Research Unit, University of Exeter
Exeter, Devon, United Kingdom
RECRUITINGForearm glucose net balance
Net balance of blood glucose across a forearm following a mixed meal tolerance test
Time frame: 3 hours
Forearm non-esterified fatty acid net balance
Net balance of blood non-esterified fatty acids across a forearm after a mixed meal tolerance test
Time frame: 3 hours
Forearm amino acid net balance
Net balance of blood amino acids across a forearm following a mixed meal tolerance test
Time frame: 3 hours
Serum insulin concentrations
Insulin concentration using ELISA assay over 4 and 8 hours following a meal
Time frame: 3 hours
Ketone concentration
Ketone concentration using colorimetric assay over 4 and 8 hours following a meal
Time frame: 3 hours
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