Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients

Zulekha Hospitals3 enrolled

Overview

A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.

Participants were categorized into three groups: Group I and Group II received neostigmine 1 mg and 2 mg, respectively, and a control group received 10 ml of normal saline. All participants received an intravenous administration of 10 mg of metoclopramide. GRV was measured every 3 hours before enteral feeding. aspiration through nasogastric (NG) or orogastric (OG) tubes was done before the next due bolus of feeding.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Gastric Reflux

Interventions

NeostigmineDRUG

two groups (Group I, n= 41) and (Group II, n= 43) received varying doses of neostigmine (1 mg and 2 mg respectively

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with a GRV \>120ml * a normal heart rateExclusion Criteria * absence of comorbidities such as diabetes and renal failure. exclusion Criteria: * Patients exhibiting new-onset arrhythmias or heart block * hypotension (systolic blood pressure less than 60 mmHg) * experiencing active gastrointestinal bleeding or receiving prokinetic medications 8-12 hours before the intervention * patients with a history of surgery in the gastrointestinal system in the past two weeks history of extrapyramidal manifestations * patients with electrolyte imbalance * pregnant patients,

Locations (1)

Al-Azhar faculty of medicine

Cairo, Egypt

Outcomes

Primary Outcomes

The risk of aspiration

The risk of aspiration in ICU patients on enteral feeding via vaso-gastric or oro-hastric tubes

Time frame: december 2022 to may 2024

Data from ClinicalTrials.gov

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