Effect of PRP Joint Cavity Combined with Acupoint Injection on Osteoarthritis of Knee Joint

Zhengzhou Revo-Gene Technology Co., LTD90 enrolled

Overview

This study collected general data from 90 patients with KOA in the outpatients and ward of Henan Provincial People's Hospital from January 2023 to December 2023 to compare the long-term effects of intra-articular PRP combined with acupoint PRP, intra-articular PRP, and intra-articular HA on symptoms in patients with mild to moderate osteoarthritis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Early Knee Osseous Arthrophlogosis

Interventions

PRP joint injection combined with acupoint injectionOTHER

PRP acupoint injection

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. The expected survival period is more than 3 months; 2. The clinical diagnosis was early knee osteoarthritis; 3. Capable of knee injections; 4. chronic joint pain or swelling (\> 4 months); 5. It meets the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2021 Edition) , and the X-ray evaluation results meet the Kellgren-Lawrence scale (K-L scale) level I to level III. Exclusion Criteria: 1. age over 80 years old; 2. K-L classification is greater than Ⅲ grade; 3. Combined with rheumatoid arthritis, severe osteoporosis, tumor, gout, obvious joint deformity and other diseases; 4. Poor compliance, not according to the provisions of treatment; 5. Pregnant and lactating women; 6. Patients voluntarily withdrew from the study; 7. Patients were lost to follow-up due to various reasons during follow-up.

Locations (1)

No.7, Wei Wu Road, Zhengzhou City

Zhengzhou, Henan, China

Outcomes

Primary Outcomes

Visual Analog Scale (VAS) score

Visual Analog Scale (VAS) score ranging from 1 to 10, with lower scores indicating less pain intensity

Time frame: Assessments will be conducted at weeks 1, 3, 6, and 12 after treatment.

Knee Society Score (KSS)

Knee Society Score (KSS), which consists of five major items totaling 200 points. Higher scores indicate better knee joint function

Time frame: Assessments will be conducted at weeks 1, 3, 6, and 12 after treatment.

Western Ontario and McMaster Universities Osteoarthritis Index

The severity of knee osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, consisting of 24 items with a total possible score of 240 points. Lower WOMAC scores indicate less severe knee osteoarthritis.

Time frame: Assessments will be conducted at 1, 3, 6, and 12 months after treatment.

Data from ClinicalTrials.gov

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