The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects. The main questions it aims to answer are: 1. The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects. 2. The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up. Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including : * A semi-structured interview to check the participants eligibility and gather demographic data. * Neuropsychological tests and questionnaires will then be administered. * A relative of the study participant will help complete questionnaires.
Music therapy appears to be highly relevant as a Non-Medication Intervention in Alzheimer s (AD) and Parkinson s disease (PD). It is said to reduce depressive symptoms following music therapy sessions in dementia . With regard to Parkinson s disease, music therapy brings benefits in terms of motor skills, communication, breathing and emotional aspects. Reviews point to the need to differentiate beneficial effects according to different pathologies. To date, no study has investigated the evolution of sensitivity to musical reward in AD. Furthermore, no study has discriminated the evolution of musical engagement in several neurodegenerative pathologies.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
120
It will take place either at the hospital or at the participant's home. This interview will consist of : * socio-demographic data collection * neuropsychological tests: * MMSE test (Mini Mental State Examination) cognitive function * RL-RI-16 test (16-item free recall/indexed recall test) * BECS test (Semantic knowledge assessment battery ) * WCST test (Wisconsin Card Sorting Test ) * Musical Cognition Test * Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire
The participant answers questionnaires: * Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire) * Questionnaire BMRQ (Barcelona Reward Music Questionnaire) * Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale) * Questionnaire LARS (Lille's Apathy Rating Scale) * Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)
Montpellier Seniors' Association
Montpellier, Hérault, France
NOT_YET_RECRUITINGCHU de Montpellier - CEPMo
Montpellier, Hérault, France
RECRUITINGCHU de Montpellier - CMRR
Montpellier, Hérault, France
NOT_YET_RECRUITINGComparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults.
Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.
Time frame: Baseline
The comparison of self- and hetero-questionnaires will be carried out within each group for each MUseQ24 dimension
Compare the results of the self-reported and hetero-reported versions of the Musical Engagement Questionnaire. Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.
Time frame: Baseline
Comparison of global cognition between Alzheimer's, Parkinson's and healthy elderly groups
Mini Mental State Examination (MMSE) scoring from 0 (minimum) to 30 (maximum), with higher scores indicating better semantic memory function.
Time frame: Baseline
Comparison of Executive Function between Alzheimer's, Parkinson's and healthy elderly groups
Wisconsin Card Sorting Test (WCST) which assesses executive functioning globally with a rule deduction task. (Scoring from 0 to 6 for the number of correct categories and 0 to 48 for the number of mistakes). The higher the number of categories, the higher the executive functioning. The higher the number of errors, the lower the executive functioning.
Time frame: Baseline
Comparison of Episodic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups
Free and Cued Recall Test (RL/RI-16), a 16 items tests scoring from 0 (minimum) to 48 (maximum), with higher scores indicating better memory recall.
Time frame: Baseline
Comparison of Semantic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups
Recognition subtest of the Battery for the Assessment of Semantic Knowledge (BECS) scoring from 0 to 40. Higher scores indicate stronger semantic memory abilities, with lower scores reflecting potential deficits in semantic knowledge.
Time frame: Baseline
Comparison of Musical Cognition between Alzheimer's, Parkinson's and healthy elderly groups
Test of Orientation in Music Therapy (TOM), scoring from 0 to 34 Higher scores represent better musical cognition abilities, while lower scores may indicate reduced cognitive processing of musical information.
Time frame: Baseline
Comparison of Semantic Musical Memory between Alzheimer's, Parkinson's and healthy elderly groups
The extension of the Test of Orientation in Music Therapy (TOM), scoring from 24 to 120. Higher scores represent better musical cognition abilities, while lower scores may indicate reduced cognitive processing of musical information.
Time frame: Baseline
Comparison of Sensitivity to musical reward between Alzheimer's, Parkinson's and healthy elderly groups
Barcelona Reward Music Questionnaire BRMQ, (scoring 20 to 100, the lower the score the lower the sensitivity to musical reward). It contains 20 items scored on a 5-point Likert scale. It contains 5 dimensions: musical search, emotional evocation, mood regulation, social reward and sensorimotor.
Time frame: Baseline
Comparison of Self-assessed musical engagement between Alzheimer's, Parkinson's and healthy elderly groups
MusEQ-24, self-reported Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.
Time frame: Baseline
Comparison of Memory recall during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups
MusEQ-24 item 22, hetero-reported (scoring 0 to 5, the lower the score the lower memory recall)
Time frame: Baseline
Comparison of emotional experience during music listening during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups
MusEQ-24 Emotion subscale, hetero-reported (scoring 0 to 5, the lower the score the lower the emotional experience)
Time frame: Baseline
Comparison of Hedonic function reward between Alzheimer's, Parkinson's and healthy elderly groups
Snaith-Hamilton Pleasure Scale (SHAPS), a 14 items scale, Score Range: 0 (minimum) to 14 (maximum). Higher scores suggest anhedonia, with lower scores indicating a greater capacity for experiencing pleasure.
Time frame: Baseline
Comparison of Affective blunting between Alzheimer's, Parkinson's and healthy elderly groups
Emotional intensity subscale of Lille's Apathy Rating Scale (LARS) a 33 items scale. The LARS is divided into 9 subscales, each scoring -4 to +4. Higher scores reflect greater affective blunting (reduced emotional intensity), while lower scores suggest a more typical range of emotional responses.
Time frame: Baseline
Comparison of Depression symptoms
Patient Health Questionnaire 9 items (PHQ-9). Score Range: 0 (minimum) to 27 (maximum), each item is rated from 0 to 3 Score Interpretation: Higher scores indicate more severe depressive symptoms, with lower scores suggesting fewer depressive symptoms or none at all.
Time frame: Baseline
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Wisconsin Card Sorting Test (WCST) for each group
correlation coefficient R
Time frame: Baseline
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the 16-item free recall/indexed recall test (RL/RI- 16) for each group
correlation coefficient R
Time frame: Baseline
Correlation between Barcelona Reward Music Questionnaire (BMRQ) and Lille's Apathy Rating Scale (LARS) subscale for each group
correlation coefficient R
Time frame: Baseline
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group
correlation coefficient R
Time frame: Baseline
Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Wisconsin Card Sorting Test (WCST) for each group
correlation coefficient R
Time frame: Baseline
Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the 16-item free recall/indexed recall test (RL/RI- 16) for each group.
correlation coefficient R
Time frame: Baseline
Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group
correlation coefficient R
Time frame: Baseline
Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group
correlation coefficient R
Time frame: Baseline
Correlation between Item 22 of the MusEQ-24 hetero-reported version and Wisconsin Card Sorting Test (WCST) for each group
correlation coefficient R
Time frame: Baseline
Correlation between item 22 of the MusEQ-24 hetero-reported version with 16-item free recall/indexed recall test (RL/RI- 16) for each group
correlation coefficient R
Time frame: Baseline
Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group
correlation coefficient R
Time frame: Baseline
Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group
correlation coefficient R
Time frame: Baseline
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