Vitamin D Metabolites as Biomarkers for the Identification of Kidney Injury in Cardiac Surgery

N/AActive Not RecruitingNCT06688994

University Health Network, Toronto46 enrolled

Overview

The investigators will be measuring vitamin D metabolites in blood samples drawn from patients undergoing cardiac surgery to determine the correlation with renal function as assessed by serum creatinine. The investigators will include 20 patients in each of the following 3 groups based on serum creatinine measured within 28-days of surgery: 1) normal kidney function (eGFR \> 60 mL/min, n=20), 2) moderate impaired kidney function, eGFR between 30 and 60 mL/min (n=20) and 3) severe kidney dysfunction eGFR \< 30 mL/min (n=20).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Kidney Injuries Chronic Renal Diseases

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria * ≥ 18 years * Patients undergoing cardiac surgery * Serum Creatinine measured with 28 days of surgery Exclusion Criteria * Exogeneous calcitriol (1,25(OH)2D3) intake * History of parathyroidectomy * Patients with liver or kidney cancer * Patients with liver disease (e.g. liver failure, cirrhosis)

Locations (1)

University Health Network-Toronto General Hospital

Outcomes

Primary Outcomes

Determine the correlation between eGFR as determined serum creatinine and vitamin D metabolites as markers of kidney function

serum creatinine (sCr) and vitamin D metabolites (specifically 25(OH)D3 and 1,25(OH)2D3) will be measured in the same blood sample to determine the incidence of AKI and CKD in patients undergoing cardiac surgery

Time frame: Up to 1 month before surgery up until POD 7