To investigate the effects of sevoflurane on respiratory parameters and respiratory inflammation in healthy and RSV-infected under general anesthesia and to propose suitable perioperative airway protection measures for children with respiratory virus infection undergoing general anesthesia.
Study Type
OBSERVATIONAL
Enrollment
97
Sevoflurane 1%\~3.5%
Propofol 9\~15mg/kg/h
First hospital of China Mdical University
Shenyang, Liaoning, China
First Hospital of China Medical University
Shenyang, Liaoning, China
Intraoperative ventilator parameters
Airway pressure(including Paw, PIP, Pplat), and pulmonary compliance.
Time frame: After induction of general anesthesia and intubation; at the end of anesthesia
Inflammation response indications
The level of NLRP3 and IL-1β measured by ELISA in the tracheal secretions of the patients
Time frame: After induction of general anesthesia and intubation; at the end of anesthesia
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