Glutamate Modulation of tDCS Over Premotor Cortex Combined With Peripheral Nerve Stimulation Promoted Observation-execution-related Cortical Excitability and Motor Learning

Beijing Sport University128 enrolled

Overview

This study aimed to investigate whether concurrent tDCS over the PMC and PNS during action observation enhance observation-execution-related motor cortex excitability and improve motor performance, and to explore the underlying mechanism

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

128

Conditions

Brain Stimulation Peripheral Nerve Stimulation Motor Observation Cortical Excitability

Interventions

tDCS + PNS with action observationDEVICE

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

sham tDCS + sham PNS with action observationDEVICE

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

tDCS + PNS without action observationDEVICE

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 33 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * normal or corrected-to-normal vision * right-handed Exclusion Criteria: * pregnancy * a history of epilepsy * implanted medical devices * history or presence of neurological, psychiatric or musculoskeletal disorders, other medical conditions, and left-handedness

Locations (1)

Beijing Sport University

Beijing, Haidian, China

Outcomes

Primary Outcomes

Motor-evoked potentials

Time frame: Before interventions, and immediately after interventions

intracortical facilitation assessed by transcranial magnetic stimulation

Time frame: Before interventions, and immediately after interventions

short-interval intracortical inhibition assessed by transcranial magnetic stimulation

Time frame: Before interventions, and immediately after interventions

Reaction times of action execution blocks

Time frame: immediately after interventions

Data from ClinicalTrials.gov

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