The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
413
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
University of California, Irvine (UCI) Health - UC Irvine Medical Center
Irvine, California, United States
Number of participants with Adverse Events (AEs) as assessed by National Cancer Institute -Common Terminology Criteria for Adverse Events version 5.0 (NCI-CTCAE v5.0)
Time frame: Up to 135 days post last treatment visit
Number of participants with Serious AEs (SAEs) as assessed by NCI-CTCAE v5.0
Time frame: Up to 135 days post last treatment visit
Number of participants with AEs meeting protocol-defined Dose-Limiting Toxicity (DLT) criteria as assessed by NCI-CTCAE v5.0
Time frame: Up to Day 28
Number of participants with AEs leading to discontinuation as assessed by NCI-CTCAE v5.0
Time frame: Up to 135 days post last treatment visit
Number of deaths as assessed by NCI-CTCAE v5.0
Time frame: Through study completion (Up to 4 years)
Concentration at the end of infusion (Cmax)
Time frame: Up to 135 days post last treatment visit
Time of maximum observed concentration (Tmax)
Time frame: Up to 135 days post last treatment visit
Area under the concentration-time curve in one dosing interval (AUC(TAU))
Time frame: Up to 135 days post last treatment visit
Overall Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST v1.1) as assessed by Investigator
Time frame: Up to 135 days post last treatment visit
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
First line of the email MUST contain NCT # and Site #.
CONTACT
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Specified dose on specified days
The Angeles Clinic and Research Institute - West Los Angeles Office
Los Angeles, California, United States
RECRUITINGLocal Institution - 0008
Aurora, Colorado, United States
NOT_YET_RECRUITINGJohn Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States
RECRUITINGNorthwell Health/ RJ Zuckerberg Cancer Center
Lake Success, New York, United States
RECRUITINGLevine Cancer Institute
Charlotte, North Carolina, United States
RECRUITINGFred Hutchinson Cancer Center
Seattle, Washington, United States
RECRUITINGUZ Gent
Ghent, Oost-Vlaanderen, Belgium
RECRUITINGRigshospitalet
Copenhagen, Capital Region, Denmark
RECRUITINGAssistance Publique Hôpitaux de Marseille - Hôpital de la Timone
Marseille, Bouches-du-Rhône, France
RECRUITING...and 11 more locations