The majority of anal squamous cell carcinomas (SCC) stem from infection with high-risk human papillomavirus (HPV). Anal SCC is rare among the general population but affects several populations disproportionately. High-risk groups are screened through anal swabs for anal cytology and detection of high risk human papillomavirus (HR HPV). HRA referral is recommended for individuals with abnormal cytology. HRA represents the only method to identify precancerous lesions of the anal canal, with only few specialists knowledgeable about it. At UZ Brussel, the investigators collected a wealth of data about HPV infection and its association with anal pathology. By establishing a comprehensive study, the investigators can delve into this data with specific research questions, conducting valuable research to provide answers to pressing clinical questions and contribute to advancements in medical understanding and treatment.
Study Type
OBSERVATIONAL
Enrollment
500
High resolution anoscopy to help evaluate anal conditions such as precancerous lesions
UZ Brussel
Jette, Belgium
RECRUITINGcomparison of the prevalence of precancerous lesions in men who have sex with men using PrEP or are HIV positive Men
Time frame: Through study completion, on average 5 years
Exploration of associations between abnormal histology and patient characteristics
Time frame: Through study completion, on average 5 years
comparison of the prevalence of precancerous lesions in different groups
Time frame: Through study completion, on average 5 years
to delineate unique features associated with HSIL in each risk group by linking patterns or characteristics
such as verrucous aspects, coarse punctuation, mosaic patterns, flat morphology, and fragility
Time frame: Through study completion, on average 5 years
Prevalence of anal cancer among the at-risk populations
Time frame: Through study completion, on average 5 years
correlation between abnormal histology and abnormal cytology, as well as HPV infection in MSM using PrEP and MSM living with HIV
Time frame: Through study completion, on average 5 years
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