The goal of this trial is to compare resistance exercise using traditional techniques and flywheel training to controls in healthy children ages nine to 13 and adults ages 18 to 50. The main questions it aims to answer are: * The degree of response to resistance exercise in children compared to adults regarding muscle hypertrophy and strength? * Is there a negative impact on the physis of children due to resistance exercise? Participants will be randomized to one of three groups, control, traditional resistance exercise, or flywheel. Following a baseline battery of tests, they will enter a 12-week training period, using leg press and leg extension. Additionally, post-training tests are conducted, and an eight-week detraining period commences followed by new tests. Researchers will compare children and adults and each intervention arm to see if children can achieve muscle hypertrophy, the degree and rate of changes in strength, and the potential impact on the physis.
The KidREx-study is an intervention study aiming to investigate the effects of two alternative forms of resistance exercise on adults and children. Exercise forms include leg press and leg extension, in either traditional weight stack machines or flywheel training machines. It has been proposed and discussed that resistance exercise would cause injury to the growth plate and even premature closure of the physis in children. Multiple studies have shown that this is not the case regarding growth height and radiography of the physis. However, the direct effects of resistance exercise on physis using magnetic resonance imaging are yet to be investigated. This study is a randomized, controlled, prospective intervention study. Two separate groups (children and adults) are included, children ages 9 to 13 and adults ages 18-50. Participants are randomly assigned to one of six arms for the twelve-week intervention period. Arms include two control groups "living as usual" (children and adults), two flywheel training groups (children and adults), and two weight stack training groups (children and adults). Throughout the intervention period, the training groups conduct a total of 30 sessions (alternating between two or three sessions per week). Following the intervention period, all participants enter an 8-week detraining phase, where no organized resistance training is conducted. At baseline, all participants conduct a test battery including vertical jump height, horizontal jump length, balance tests, and tests of muscle activity in the specific training machines and in an isokinetic dynamometer. In conjunction with the first exercise bout, venous blood samples are obtained from both adults and children, and skeletal muscle biopsies from m. vastus lateralis are obtained from the adults. This procedure is repeated after 12 weeks of training and following the 8-week detraining period. Outcomes related to this, blood samples and muscle tissue, beyond the fiber-specific hypertrophy, will be subject to ancillary studies. The investigators hypothesize that weight stack training and flywheel training will result in muscle adaptation in both adults and children, where the rate of adaptation is faster for the flywheel training group. Expected muscle adaptation includes an increase in muscle hypertrophy, strength, and functional strength-related outcomes (balance, vertical jump height, and standing long jump). Additionally, the investigators hypothesize that the growth plate of pre- and intra-pubertal children will not be affected negatively by resistance exercise.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
91
FW is conducted in a leg extension machine (LegExx, Exxentric, Stockholm, Sweden) and leg press machine (YoYo™ Leg Press, nHANCE, Sweden).
WS is conducted in a leg extension machine (Seated leg press, Nordic Gym, Bollnäs, Sweden) and a leg press machine (Seated leg extension, Nordic Gym, Bollnäs, Sweden)
Department of Orthopaedic Surgery, Höglandssjukhuset District Hospital Eksjö
Eksjö, Region Jönköping County, Sweden
Change from Baseline Muscle Volume Following 12 Weeks of Resistance Exercies
The groups of children and adults will undergo magnetic resonance imaging of the anterior thigh in a standardized fashion. Subsequently, the muscle volume is calculated by contouring cross-sectional area of muscle. Primary analysis is muscle growth of the m. quadriceps femoris in the two active comparator groups compared to the control group.
Time frame: Time Frame: Before intervention start (0 weeks) and following twelve weeks of training (12 weeks)
Changes in muscle thickness
The group of adults and children undergo ultrasound scans of the anterior thigh in a standardized fashion. The scans will encompass all four heads of the m. quadriceps femoris.
Time frame: Time Frame: Prior to intervention start, biweekly during the intervention period (i.e., after two, four, six and eight weeks). Additional scans will be performed following the end of intervention (12 weeks) and the end of detraining (20 weeks).
Change from baseline in rate of physeal closure following resistance exercise
The children will undergo magnetic resonance imaging of the physis of the knee in the non-dominant limb. The degree of closure of the growth plates of the distal femur and proximal tibia will be graded.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Change in muscle volume at 20 weeks
The groups of children and adults will undergo magnetic resonance imaging of the anterior thigh in a standardized fashion. Subsequently, the muscle volume (cm3) is calculated by contouring cross-sectional area of muscle. Primary analysis is muscle growth of the m. quadriceps femoris in the two active comparator groups compared to the control group.
Time frame: Time Frame: Before intervention start (0 weeks) and end of intervention (12 weeks) compared to volume following the detraining period (20 weeks)]
Changes in peak torque during isokinetic concentric and eccentric knee extension and flexion
Concentric and eccentric peak torque (Nm) of the knee extensors and flexors are measured in an Isokinetic dynamometer. Peak torque is measured at 60,120,180 and 300 deg/ sec during concentric actions and 60 deg/sec during eccentric.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in power during isokinetic concentric and eccentric knee extension and flexion
Concentric and eccentric power (W) of the knee extensors and flexors are measured in an Isokinetic dynamometer. Power is measured at 60,120,180 and 300 deg/ sec during concentric actions and 60 deg/sec during eccentric.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in work during isokinetic concentric and eccentric knee extension and flexion
Concentric and eccentric work (J) of the knee extensors and flexors are measured in an Isokinetic dynamometer. Work is measured at 60,120,180 and 300 deg/ sec during concentric actions and 60 deg/sec during eccentric.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in muscle activity during isokinetic concentric and eccentric knee extension and flexion measured using sEMG
Concentric and excentric actions of the knee extensors and flexors are measured in an isokinetic dynamometer using surface electromyography (sEMG) to capture muscle activity from the quadriceps and hamstring musculature. Muscle activity is measured in volts and following post-processing presented in absolute numbers or relative percentages of maximal voluntary contraction (MVC). MVC is acquired during maximal isometric concentric contraction at 60 degrees.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in power during flywheel resistance exercise
All participants perform test sessions in a flywheel leg press and leg extension where power (W) during the concentric and eccentric face is measured using a rotational encoder.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in muscle activation with flywheel resistance exercise measured using sEMG
All participants perform test sessions in a flywheel leg press and leg extension where muscle activity of the knee extensors and knee flexors are recorded during two sets and seven repetitions in each machine. Muscle activity (mV) will be adjusted to maximal voluntary contractions (MVC) measured at 90 degrees of knee flexion and extension. Concurrently the joint angel is measured using a goniometer during the entire range of motion.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in power during weight stack resistance exercise
All participants perform test sessions in a weight stack leg press and leg extension where power (W) during the concentric and eccentric face is measured using a linear encoder.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in muscle activation during weight stack resistance exercise measured using sEMG
All participants perform test sessions in a weight stack leg press and leg extension where muscle activity of the knee extensors and knee flexors are recorded using electromyography. During two sets and seven repetitions in each machine. Muscle activity (mV) will be adjusted to maximal voluntary contractions (MVC) measured at 90 degrees of knee flexion and extension. Concurrently the joint angel is measured using a goniometer during the entire range of motion.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in power output during training
Power (W) is measured during all training sessions in both training groups. In the flywheel resistance exercise groups using a rotational encoder and in the flywheel stack machine using a linear encoder. Training is performed alternating two to three times weekly during the intervention period.
Time frame: Time Frame: Continuous power measurements during all training sessions, weeks 1 through 12 weeks
Changes in Balance
The participants will perform two standardized sets of tests aimed to quantify their balance, including a series of perturbations and modified-SOT.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in vertical jump height
The participants will perform two bouts of vertical countermovement jumps, with arms locked upon the hips and with free arms respectively. This will be performed on a force plate and using a motion tracking system.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in isometric maximum strength
All participants will perform an isometric maximal contraction of the knee extensors with a 90° knee angle using a force sensor connected in serie with the foot pad in the knee extension weight stack device
Time frame: Time Frame: Baseline (0 weeks), 2 weeks of intervention, 4 weeks of intervention, 6 weeks of intervention, 8 weeks of intervention and post intervention (12 weeks) and post detraining (20 weeks)
Changes in standing long jump
The participants will perform three trials of standing long jump. If there is an continues upwards trend, the participants are allowed further trials until a plateau is reached.
Time frame: Time Frame: Baseline (0 weeks), 2 weeks of intervention, 4 weeks of intervention, 6 weeks of intervention, 8 weeks of intervention and post intervention (12 weeks) and post detraining (20 weeks)
Change in type I-fiber cross-sectional area.
Resting muscle biopsies are acquired from the m. vastus laterals muscle of the adults. Fiber-specific staining is performed and cross-sectional area is calculated
Time frame: Time Frame: Baseline (0 weeks), two weeks of training, six weeks of training, post training (12 weeks) and post detraining (20 weeks).
Change in type II-fiber cross-sectional area.
Resting muscle biopsies are acquired from the m. vastus laterals muscle of the adults. Fiber-specific staining is performed, and cross-sectional area is calculated
Time frame: Time Frame: Baseline (0 weeks), two weeks of training, six weeks of training, post training (12 weeks) and post detraining (20 weeks).
Changes in testosterone levels in children during the intervention
All child participants will donate blood at baseline, post training and post detraining to assess changes in testosterone (nmol/L) levels.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in estradiol levels in children during the intervention
All child participants will donate blood at baseline, post training and post detraining to assess changes in estradiol (pmol/L) levels.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Changes in IGF-1 levels in children during the intervention
All child participants will donate blood at baseline, post training and post detraining to assess changes in insulin-like growth factor 1 (ug/L) levels.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
Questionnaire based assessment of physical self-esteem (children)
Physical self-esteem will be assessed using a translated version (Swedish) of the questionnaire The Children and Youth Physical Self-Perception Profile (CY-PSPP). Total score from 36 to 144 where 144 is the best result.
Time frame: Time Frame: Baseline (0 weeks), post training (12 weeks) and post detraining (20 weeks)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.