Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection

Northwestern University80 enrolled

Overview

Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM). The goal of this study is to look at and compare the clinical results of all the different approved methods (living vs. Deceased, whole organ vs. Split, one staged vs. Two staged) used to perform a standard liver transplant procedure for recipients with CRLM. Investigators will look at things like different procedure results, recovery in the hospital, and survival rates one year after the transplant. Investigators will also take blood samples from participants to be used in future research. All the transplant methods the investigators are comparing are standard practices approved by the United Network of Organ Sharing (UNOS).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Liver Transplant Surgery Colorectal Cancer Metastatic Colon Cancer Liver Metastases

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion: 1. All Patients of either gender ≥ 18 years of age who are listed for Liver transplant candidates at Northwestern with liver metastases due to colorectal cancer (CRLM). 2. Subjects must be able to provide informed consent themselves and without the use of a legally authorized representative (LAR), to be determined by the PI or Sub-I at the time of Consent. Exclusion: 1. Adults unable to consent 2. Pregnant Women 3. Certain clinical/surgical/anatomical parameters, at the discretion of the PI.

Outcomes

Primary Outcomes

Graft and Patient Survival Outcomes

Graft survival will be measured as the time from transplantation to graft failure, or re-transplantation date.

Time frame: From liver transplant to 12 months

Secondary Outcomes

Outcomes of liver transplant recipients

Evaluate outcomes (e.g., complications or surgical outcomes) of liver transplant (LT) recipients.