Posaconazole Tablet As Primary Prophylaxis of HSCT Patients with Gastrointestinal GVHD

Inclusion Criteria: 1. Patients with hematologic diseases who undergoes hematopoietic stem cell transplantation. 2. Patients who receive Posaconazole tablet as primary prophylaxis of invasive fungal disease. 3. Patients developing or developed acute gastrointestinal GVHD which require systemic immunosuppressive therapy of corticosteroids with- or-without other immunosuppressive agents including calcineurin inhibitors. Gastrointestinal GVHD grades (I-IV) were recorded according to the Glucksberg criteria. 4. Patients themselves or their authorized clients agree to participate in the clinical study and sign the informed consent Exclusion Criteria: 1. refuse to enroll 2. patients have known hypersensitivity or other serious adverse reaction to any azole antifungal therapy, or to any other ingredient of the study medication used. 3. pregnant or lactating females 4. take drugs known to interfere with azole antifungal agents, including terfenadine, cisapride and ebastine, within 24h before Posaconazole application; astemizole at enrollment or within 10 days before Posaconazole application; or cimetidine, rifampin, carbamazepine, phenytoin, rifamycin, barbiturates, isoniazid, catharanthine and anthracyclines within 24 h before Posaconazole application 5. have an ECG with a prolonged QTc interval (QTc greater than 500 ms); 6. have severe renal insufficiency, alanine transaminase, aspartate transaminase, alkaline phosphatase or total bilirubin levels more than two-times the upper limit of normal; 7. patients are expected to survive no more than 72 h; 8. Those with evidence of active fungal infection within 3 weeks prior to enrollment