This randomized controlled clinical study investigates the effectiveness of Spirulina gel and Spirulina nanoparticles gel in treating Stage II Grade B periodontitis. The research aims to compare the two formulations in terms of clinical, radiological, and biochemical outcomes, such as pocket depth reduction, alveolar bone density improvement, and inflammatory marker levels. The study seeks to provide insights into the potential of Spirulina-based therapies for enhancing periodontal health.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
15
A gel without active Spirulina components applied as a control intervention.
A conventional Spirulina gel formulation applied as a periodontal therapy.
A novel Spirulina nanoparticles gel formulation applied as a periodontal therapy.
Doctor Mohamed Samir Periodontal and Implantology Clinic
El-Sheikh Zayed City, Cairo Governorate, Egypt
Reduction in Probing Pocket Depth (PPD)
The mean reduction in probing pocket depth in millimeters (mm) at periodontal sites treated with Spirulina gel and Spirulina nanoparticles gel.
Time frame: at baseline, 1 month , 3 months, 6 months
Radiographic Bone Density Improvement
Changes in alveolar bone density measured using radiographic imaging techniques.
Time frame: at baseline and after 6 months
Biochemical Marker Levels
Reduction in inflammatory markers specifically Superoxide dismutase enzyme levels in gingival crevicular fluid.
Time frame: Measured at baseline, 1 month ,3 months, and 6 months
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