ReadMap: Reading in Stroke Alexia and Typical Aging

Georgetown University300 enrolled

Overview

Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups. Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Aphasia Stroke Alexia

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: Stroke Survivors: * Age \>= 18 * Learned English at 8 years or younger * Brain injury resulting from stroke Controls: * Age \>= 18 * Learned English at 8 years or younger Exclusion criteria for all groups: * History of other brain disorder that could interfere with our ability to interpret results (e.g., Multiple sclerosis, dementia, head injury causing loss of consciousness) * Severe psychiatric condition that would interfere with participation in the study * History of diagnosed learning disorder * Hearing or vision loss that interferes with performance on behavioral tests even after correction with glasses/hearing aids. * Inability to follow study procedures despite maximal support Additional exclusion criteria for MRIs: * Presence of metal in the body that is incompatible with MRI * Pregnancy * Claustrophobia

Outcomes

Primary Outcomes

MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)

Part of MRI sequence that measures deep grey matter structure.

Time frame: Collected within 1 month of behavioral testing

DTI (Diffusion Tensor Imaging)

Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.

Time frame: Collected within 1 month of behavioral testing

Behavioral testing

Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.

Time frame: Collected within 1 month of MRI