This study will investigate the association between clonal hematopoiesis and other conditions. Clonal hematopoiesis (CH) refers to the mutations in a person's stem cells which commonly affect people as they get older. These mutations have notably been linked to increased risk of certain cancers as well as increased risk of heart disease.
Objectives: * To develop the CHIVE Registry with CH patients or patients with elevated risk for CH in order to better characterize associated clinical outcomes and co-morbidities in these populations * To improve understanding of cardiovascular phenotypes and risk of patients with known Clonal Hematopoiesis of indeterminate potential (CHIP) or Clonal Cytopenias of undetermined significance (CCUS) * To investigate prognostic significance of CH mutations for the development hematologic malignancies * To generate a CHIVE Biorepository to acquire patient samples to study the natural history of CH, and to make available to CH investigators.
Study Type
OBSERVATIONAL
Enrollment
800
Blood will be taken from participants already undergoing blood collection
Undergo saliva collection
Bone marrow will be taken from participants already undergoing bone marrow collection
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, United States
RECRUITINGCHIVE Registry
Aggregate data will be utilized to better understand the association between clonal hematopoiesis and other conditions
Time frame: Up to approximately 120 months
CHIVE Biorepository
Number of biological samples collected and stored (Blood, saliva, bone marrow) for future studies.
Time frame: Up to approximately 120 months
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