The purpose of this study is to assess the real-world effectiveness of deucravacitinib treatment in adults diagnosed with moderate-to-severe plaque psoriasis
Study Type
OBSERVATIONAL
Enrollment
350
As prescribed by treating clinician
Physician's Global Assessment (PGA) 0/1 response
Time frame: Baseline and at months 4, 12, 18 (optional), and 24
Dermatology Life Quality Index (DLQI) 0/1 response
Time frame: Baseline and at months 4, 12, 18 (optional), and 24
Time from date of treatment initiation to date of discontinuation
Time frame: Up to 24 months
Change in percentage involved Body Surface Area (BSA) from start of deucravacitinib treatment
Time frame: Baseline and at months 4, 12, 18 (optional), and 24
Change in patient reported symptom burden as assed by the 100-point Visual Analog Scale (VAS) - Itch
Time frame: Baseline and months 1, 4, 12, 18 (optional) and 24
Change in patient reported symptom burden as assed by the 100-point Visual Analog Scale (VAS) - Skin pain
Time frame: Baseline and months 1, 4, 12, 18 (optional) and 24
Change in patient reported symptom burden as assed by the 100-point Visual Analog Scale (VAS)] - Fatigue
Time frame: Baseline and months 1, 4, 12, 18 (optional) and 24
Physician's Global Assessment (PGA) score change from start of deucravacitinib treatment to follow-up
Time frame: Baseline and at months 4, 12, 18 (optional), and 24
Dermatology Life Quality Index (DLQI) score of ≤5
Time frame: Baseline and at months 1, 4, 12 18 (optional) and 24
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Chu Amiens Picardie - Site Sud
Amiens, France
RECRUITINGCabinet Médical Elisabeth Lion
Angers, France
RECRUITINGCh Victor Dupouy
Argenteuil, France
RECRUITINGLocal Institution - 089
Argenteuil, France
COMPLETEDCH ARRAS
Arras, France
RECRUITINGCabinet Dermatologie
Bordeaux, France
RECRUITINGCabinet Dermatologie
Bordeaux, France
RECRUITINGCentre Hospitalier William Morey - Hématologie
Chalon-sur-Saône, France
RECRUITINGLocal Institution - 053
Clermont-Ferrand, France
COMPLETEDCHU Dijon
Dijon, France
RECRUITING...and 38 more locations
Body Surface Area (BSA) of ≤ 3%
Time frame: Baseline and at months 4, 12, 18 (optional), and 24
Body Surface Area (BSA) of ≤ 1%
Time frame: Baseline and at months 4, 12, 18 (optional), and 24
Reasons for deucravacitinib treatment discontinuation
Time frame: Up to 24 months