The aim of the study is to compare surgical outcomes (intra and post-operative complications) and sperm retrieval rates between conventional microsurgical-assisted testicular sperm extraction (m-TeSE - Group A) and testicular sperm extraction performed with surgical loupes (l-TeSE - Group B) in adult males with non-obstructive azoospermia.
Objective: To compare surgical outcomes and sperm retrieval rates (SRR) between conventional microsurgical-assisted testicular sperm extraction (m-TeSE - Group A) and testicular sperm extraction performed with surgical loupes (l-TeSE - Group B) in adult males with non-obstructive azoospermia (NOA). A multicentric prospective randomized trial was conducted from March 2022. Adult males with NOA without genetic alterations who agreed to participate in the study and signed the required informed consent were enrolled. SRR, intra and post-operative complications (according to Clavien-Dindo classification), hormonal profile tchanges were considered as outcomes during the follow up period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
42
The microscope provides a direct examination of the testicular parenchyma at 20-25x magnification.
Surgical loupes offer magnification of 3.5-5x.
Molinette - AOU Città della Salute e della Scienza di Torino
Turin, Italy
Positive sperm retrieval
Number of sperm retrieval
Time frame: immediately after the surgery
Histology
Normal testicular biopsy or Hypospermatogenesis or Germ cell arrest or Sertoli cell-only syndrome or Seminiferous tubule hyalinization or CIS or Immature testis
Time frame: immediately after the surgery
Johnsen score
Number according to Johnsen score
Time frame: immediately after the surgery
Sperm vials stored
Number
Time frame: immediately after the surgery
Operative time
Minutes
Time frame: immediately after the surgery
Complications
Clavien dindo classification
Time frame: through study completion, an average of 1 year
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