A Study on Switching From Daily DPP-4 Inhibitor to HSK7653 in Type 2 Diabetes Patients

Inclusion Criteria: * Age ≥18 and Age ≤75 years * T2DM patients, * During the 12 weeks before screening, on the basis of diet control and exercise therapy, patients only regularly received daily DPP-4 inhibitors (such as sitagliptin, vildagliptin, saxagliptin, linagliptin, alogliptin and retagliptin , etc.) or combined with metformin (with a metformin dose of ≥ 1500 mg/day, or the maximum tolerated dose \< 1500 mg/day but ≥ 1000 mg/day); * HbA1c ≥6.5% and HbA1c \<8.0% * FPG \<10.0 mmol/L * BMI ≥19 and BMI ≤ 35 kg/m2 (Body Mass Index) Exclusion Criteria: * Non-type 2 diabetes: Type 1 diabetes, gestational diabetes or other special types of diabetes. * The presence of any of the following medical histories or conditions at the time of screening: * History of diabetic ketoacidosis or hyperglycemic hyperosmolar state within the recent 6 months; * History of ≥2 episodes of severe hypoglycemia within the last 6 months; * History of malignant tumors within the recent 5 years (except for cured basal cell carcinoma of the skin and cervical carcinoma in situ), or currently being evaluated for potential malignant tumors. * Presence of severe mental disorders or language barriers, unwilling or unable to fully understand and cooperate. * History of drug abuse within the past 5 years * Previous history or clinical evidence of acute or chronic pancreatitis. * Using other drugs that may affect blood glucose metabolism within 12 weeks prior to screening, including systemic glucocorticoids (except for inhaled or topical ones), growth hormones, etc. * Any laboratory test index meeting the following criteria: * Hemoglobin \< 110 g/L (for males) or \< 100 g/L (for females). * Alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) \> 3 times the upper limit of the normal value. * Total bilirubin (TBIL) \> 2 times the upper limit of the normal value. * Fasting triglyceride (TG) \> 5.7 mmol/L. * Estimated glomerular filtration rate (eGFR) calculated using the CKD-EPI formula \< 45 mL/min/1.73m². * Known to be allergic to the investigational products or related excipients.