Biomarkers Related to PSCI: An fNIRS Study

Dingqun Bai60 enrolled

Overview

This is an fNIRS study performed to identify biomarkers related to post-stroke cognitive impairment.

This was an initial screening and preliminary intervention study. Both healthy subject and stroke patients will be included in this study. Brain functional activation of each subject during the cognitive task (Stroop task, 1-back task and verbal fluency test) will be evaluated using functional near-infrared spectroscopy (fNIRS). Cognitive function related scale assessment included Mental State Examination Scale (MMSE), Montreal Cognitive Assessment (MoCA), drawing clock test (DCT), Shape trials test A.B (STT-A, STT-B), standardized digital modal test (SDMT), auditory verbal learning test-Huashan version (AVLT-H), and activity of daily living (ADL) scale will be used to evaluate the function of each patient. Biomarkers related to post-stroke cognitive impairment will be identified by by comparing differences in brain activation and brain network connectivity between patients and healthy subjects.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Stroke Cognitive Decline

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Stroke patients: 1. Diagnosis of stroke confirmed by neuroimaging (CT or MRI) 2. 18-80 years old 3. Able to complete the cognitive task 4. Able to follow instructions to complete the trial 5. Patients who signed an informed consent form. Healthy Subjects: 1. No abnormalities on cranial 2. 18-80 years old 3. Able to complete cognitive task 4. Able to follow instructions to complete the trial 5. not taking medications. 6. Subjects who signed an informed consent form. Exclusion Criteria: Stroke patients: 1. Inability to tolerate the test due to organic diseases 2. Serious mental illness that prevents them from cooperating with or tolerating the trial 3. Pregnant or lactating women 4. Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction. Healthy Subjects: 1. Inability to tolerate the test due to organic diseases 2. Serious mental illness that prevents them from cooperating with or tolerating the trial. 3. Pregnant or lactating women 4. Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction

Locations (1)

Department of Rehabilitation Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing,

Chongqing, Chongqing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Preliminary screening of brain function biomarkers for post-stroke cognitive impairment

Comparison of differences in brain activation \[HbO2 (mmol/L\*mm)\] between patients with post-stroke cognitive impairment and patients without post-stroke cognitive impairment or healthy subjects

Time frame: 1 day

Central Contacts

Dingqun Bai

CONTACT

023-89011334 baidingqun@hospital.cqmu.edu.cn

Defei Chen

CONTACT

+8615188017034 2283273437@qq.com

Data from ClinicalTrials.gov

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