Assessing Gut Microbiome Changes Before and After an Oral Nutritional Supplement Intake Using the SIMBA Capsule in Diabetic Participants

Inclusion Criteria: 1. Aged 40-65 years old at the inclusion of the study, both female and male subjects. 2. Has type 2 diabetes as evidenced by their medical history charts and is able to maintain number of medications, type and dose throughout the duration of the study. 3. Has HbA1c ≥ 6.5% and ≤ 9.5% based on a blood sample collected at the Screening Visit, documented within the past month or referred by a medical doctor. 4. Normal to overweight (BMI 20-29.9). 5. Weight is stable (has maintained current body weight within 3 kg) for the two months prior to the Baseline Visit. 6. Is taking a maximum of 3 oral anti-diabetic drugs, one of which must be Metformin. Other class of medications permitted include: Sulfonylurea, SGLT2 inhibitors, and DPP4 inhibitors. 7. Either a male or a non-pregnant, non-lactating female, at least 6 weeks postpartum prior to the Baseline Visit. 8. Willingness to follow the protocol as described, including consumption of study product per the protocol and completing any forms/questionnaires needed throughout the study. 9. The participant is willing to refrain from taking non-study diabetes-specific oral nutritional formulas over the entire course of the study. 10. Willing to maintain their diet and physical activity levels during the study. 11. Able to swallow a 25mm length and 9mm width sized capsule. 12. At least a four-week washout period between the completion of a previous research study that required ingestion of any study food or drug and their start in the current study. Signed Informed Consent; willing and able to comply with study procedures Exclusion Criteria: 1. Confirmed type 1 diabetes and/or had a history of diabetic ketoacidosis. 2. Use of exogenous insulin or GLP1 agonists for glucose control. 3. Using diabetes-specific oral nutritional supplements(s), (e.g. Glucerna®, Boost etc.) defined as more than one eating occasion per week within the past 4 weeks (those users who can stop using such products for ≥4 weeks before baseline visit need not be excluded). 4. Follows a non-typical eating pattern such as very low carbohydrate diet (e.g., Adkins diet, ketogenic diet, high protein diet). 5. Has eating disorder, severe dementia or delirium, history of significant neurological or psychiatric disorder, alcoholism, substance abuse or other conditions that may interfere with study product consumption or compliance with study protocol procedures in the opinion of the investigators. 6. Galactosemia and lactose intolerance 7. A chronic disease which in the opinion of the investigator, would adversely affect study safety or outcome. Such as, but not limited to * A significant cardiovascular event within 6 months prior to study entry or history of congestive heart failure, per physician evaluation. * End-stage organ failure (such as end-stage renal disease) or is post-organ transplant. * Current or history of renal disease or on dialysis or severe gastroparesis. * Current diagnosed hepatic disease such as liver cirrhosis or late-stage liver fibrosis. Participants with prevalent angina will not be excluded. 8. A chronic, contagious, infectious disease, such as active tuberculosis, Hepatitis C, or HIV. 9. Subject has current active malignant disease or was treated within the last 6 months for cancer, except basal or squamous cell skin carcinoma, prior to enrollment. 10. Taking any herbals, dietary supplements, or medications during the past four weeks prior to baseline visit that could profoundly affect (in the opinion of the principal investigator or site physician) blood glucose, body weight, muscle, metabolism, appetite or microbiome (e.g. orlistat, contrave) (naltrexone/bupropion), Qsymia (phentermine/topiramate), Belviq (lorcaserin), incretin mimetics, other drugs indicated for weight loss, cannabis, glucocorticoids, prebiotics and probiotic supplements). Those users who have stopped using such supplements/ medications for ≥4 weeks prior to baseline need not be excluded). 11. Use of any medications in the week prior to the screening study visit, unless part of regular treatment, that could substantially alter gastrointestinal motor function (e.g., opioids, anticholinergics, GLP-1 analogues); laxative use is allowed if it is kept unchanged in the week prior to the SIMBA capsule ingestion timepoints. Proton pump inhibitors (PPIs) are allowed provided a wash-out period of 48 hours is respected before swallowing the SIMBA capsules and PPI treatment is resumed only 4 hours thereafter. \- If willing prokinetic use can be discontinued for the study duration, with a washout period of 2 weeks 12. Antibiotic use (except for topical use) ≤ 12 weeks prior to screening. Potential participants may be eligible once a 12-week washout is completed. 13. Current infection (requiring medication and antibiotics), inpatient surgery or received systemic corticosteroid treatment \[except for inhaled (includes nasal), topical, and ophthalmic steroids\] in the last 3 months. 14. Prior gastrointestinal disease, surgery, or radiation treatment which, in the Investigator's opinion, would interfere with consumption or digestion or absorption of study product, lead to intestinal structuring or obstruction with a risk of capsule non-excretion, including, e.g., achalasia, eosinophilic esophagitis, cancer diagnosis or previous esophageal, gastric, small intestinal, or colonic surgery. Appendectomy or cholecystectomy more than 3 months before the screening visit is acceptable. \- Diagnosed with Crohn's disease, ulcerative colitis or celiac disease. 15. History of known structural gastrointestinal abnormalities such as structures or fistulas leading to mechanical obstruction. 16. Organic motility disorder, including gastroparesis, intestinal pseudo-obstruction, systemic sclerosis, Ogilvie's syndrome. 17. History of oropharyngeal dysphagia, or other swallowing disorder with a risk of capsule aspiration. 18. History of less than three (3) bowel movements per week. 13) Consumption of probiotic or prebiotic capsule supplements within 1 month prior to screening. Potential participants may be eligible once a 1-month washout is completed. 19. Any prior Fecal Microbiota Transplantation. 20. Colon cleanses/bowel prep for 2 weeks. 21. Clotting or bleeding disorders (the use of Plavix® or a similar anticoagulant drug with no reported difficulty during blood draws will be allowed as per physician's opinion). 22. Has blood or blood-related diseases (e.g. hemophilia, thalassemia, sickle cell disease, hereditary spherocytosis, glucose-6-phosphate dehydrogenase deficiency). 23. Received a blood transfusion within the last 3 weeks. 24. Allergic or intolerant to any ingredient found in the study products. 25. Habitually engages in strenuous exercise (e.g., high intensity aerobic exercise, including heavy physical labor), duration of 1 hour or longer, 3 or more times per week. Potential participants may be eligible to participate if their levels exercise are reduced. 26. Participant is actively enrolled in a weight loss program. 27. Are scheduled for an MRI at any time during the study. Potential participants may be eligible to participate once their MRI procedure is completed. 28. Pregnant or breastfeeding. 29. Planning to become pregnant.