The aim of this cross-sectional, descriptive analysis is to compare 3 different ultrasound-based protocols to measure the internal jugular vein pressure (uJVP) in healthy individuals.
Proper hydration is crucial for health, and imbalances-like dehydration or fluid overload-can cause serious health problems including increased morbidity, hospitalization rate, and even mortality. Currently, assessing hydration is challenging, and there is no standardized method in clinical use. Ultrasound (US) of the internal jugular vein (IJV) and ultrasound-guided estimation of jugular venous pressure (uJVP) is a promising, non-invasive method to assess the hydration status. Several measure methods have been described, however, there is no univocal protocol for US IJV-assessment. In this study, three existing protocols including 4 measurements are compared to measure uJVP, which reflects the body's fluid balance. The study aims to find out which method is most accurate, easy to perform, and consistent when done by the same or different medical professionals. They will also look at how long each method takes and how acceptable these tests are to participants. The study is performed in healthy individuals and all 4 measurements are applied cross-sectional during one visit. The whole ultrasound assessment will have a duration of maximum 45 minutes. For all protocols, uJVP will be calculated by measuring with a ruler the vertical distance between IJV-height and sternal angle (cm) and then adding 5cm to this value. Protocol 1: IJV tapering portion is portrayed in a transverse view. The IJV height is marked and measured as soon as IJV is smaller than Common Carotid Artery (CCA) throughout the whole respiratory cycle. Protocol 2: IJV tapering portion is portrayed in a transverse view. The IJV height is marked and measured as soon as IJV is completely collapsed throughout the whole respiratory cycle. Protocol 3: IJV tapering portion is portrayed in a longitudinal view. The IJV height at the end of expiration is marked and measured at the following two positions: 1. Measurement 1: at the very end of the tapering portion (collapsing point / top of pulsation). 2. Measurement 2: at the beginning of the tapering portion (taper point).
Study Type
OBSERVATIONAL
Enrollment
30
Protocol 1: IJV tapering portion is portrayed in a transverse view. With a skin marker, the IJV height is marked and measured as soon as IJV is smaller than CCA throughout the whole respiratory cycle. Protocol 2: IJV tapering portion is portrayed in a transverse view. With a skin marker, the IJV height is marked and measured as soon as IJV is completely collapsed throughout the whole respiratory cycle. Protocol 3: IJV tapering portion is portrayed in a longitudinal view. With a skin marker, the IJV height at the end of expiration is marked and measured at the following two positions: 1. Measurement 1: at the very end of the tapering portion (collapsing point / top of pulsation). 2. Measurement 2: at the beginning of the tapering portion (taper point).
University Hospital Basel
Basel, Switzerland
Variance analysis
Percentage of participants differing \> 1 Standard Deviation (SD) from the expected value of Ultrasound-guided Jugular Venous Pressure (uJVP) measured in cm for each of the 3 protocols
Time frame: The whole ultrasound assessment will have a duration of maximum 45 minutes
Interpersonal variance analysis
Interpersonal variance analysis of the results for uJVP (cm) for each of the 3 different protocols, as well as for collapsibility index (%) and Jugular Vein Diameter (JVD) ratio
Time frame: The whole ultrasound assessment will have a duration of maximum 45 minutes
Intrapersonal variance analysis
Intrapersonal variance analysis of the results for uJVP (cm) for each of the 3 different protocols, as well as for collapsibility index (%) and JVD ratio
Time frame: The whole ultrasound assessment will have a duration of maximum 45 minutes
Timepoint-dependent Intrapersonal variance analysis
Intrapersonal variance analysis according to timepoint of US-assessment (first 15 participants vs last 15 participants)
Time frame: The whole ultrasound assessment will have a duration of maximum 45 minutes
Duration of the US assessment
Duration of the US assessment (minutes): interpersonal and intrapersonal variance analysis, protocol 1 vs 2 vs 3
Time frame: The whole ultrasound assessment will have a duration of maximum 45 minutes
Descriptive analysis
Descriptive analysis of analogue Visual Analogue Scale (VAS) Score data about acceptance of the 3 different US assessment protocols
Time frame: The whole ultrasound assessment will have a duration of maximum 45 minutes
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