The Effect of Sevoflurane on Haemodynamics

Children's Hospital of Fudan University40 enrolled

Overview

Cardiac output (CO) is measured using Mostcare. Mean systemic filling pressure (MSFP) and vascular resistances are calculated using venous return curves constructed by measuring steady-state arterial and venous pressures and cardiac output (CO) during inspiratory hold manoeuvres at increasing plateau pressures. Measurements are performed at three incremental levels of targeted sevoflurane concentrations.

Tracheal intubation is performed after anesthesia induction with sevoflurane. Radial arterial is cannulated and pressure transducer is connected to MostCare (core technique PRAM). HR, MAP, CVP, CO, SVR, PPV, and dp/dt are recorded at three incremental levels of targeted sevoflurane concentrations. MSFP and vascular resistances are calculated.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sevoflurane Cardiac Output Venous Return Vascular Resistance

Eligibility

Sex: ALLMin age: 3 YearsMax age: 10 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Association of Anesthesiologists (ASA)physical status score I-III * major elective surgery that dictates the use of invasive hemodynamic monitoring including CVP and continuous arterial blood pressure monitoring. Exclusion Criteria: * symptomatic peripheral vascular disease or pulmonary disease * aberrant cardiovascular anatomy * significant valvular regurgitation * severe arrhythmia

Locations (1)

Children's hospital of Fudan university

Shanghai, China

Outcomes

Primary Outcomes

cardiac output

Cardiac output is monitored using Mostcare via a radial arterial catheter connected to the pressure transducer.