Remote ischaemic pre-conditioning (RIPC) has been recognized as a low-cost, non-invasive intervention method by applying brief ischaemia and reperfusion on an arm or a leg. Previous studies have mainly focused on the organoprotective effects of RIPC in patients undergoing cardiac surgery. However, whether it has an organ-protecting effect is still highly debated. We aimed to determine whether intensive RIPC can prevent from negative inflammatory response and organ dysfunction as well as postoperative complications in patients undergoing cardiovascular surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
500
8 cycles of 5-minute inflation and 5-minute deflation on 2 upper and lower limbs with a blood pressure cuff
8 cycles of 5-minute inflation to a pressure of 20 mm Hg followed by 5-minute cuff deflation.
The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
∆SOFA
the change in sequential organ failure assessment score \[∆SOFA\]) was defined as the difference between the mean total postoperative SOFA score, calculated maximally to the 9th postoperative day, and the basal SOFA score.
Time frame: within the prior 7 days after cardiac surgery.
Plasma interleukin-1 levels
Plasma interleukin-1 levels within the prior 7 days after cardiac surgery.
Time frame: within the prior 7 days after cardiac surgery.
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