Postoperative Clinical and Neurophysiological Assessment of Patients After Open Heart Surgery

Ain Shams University80 enrolled

Overview

This study aims to investigate postoperative clinical, cognitive and neurophysiological assessment of patients after open heart surgery among sample of Egyptian patients.

Coronary artery bypass grafting (CABAG) is one of the most common major surgical procedures, as more than 800,000 patients worldwide undergo myocardial revascularization procedures every year. Cardiopulmonary bypass (CPB) is an extracorporeal circulation procedure that assists the operation of cardiac and great vessels and is associated with perioperative morbidity and mortality. Preoperative neurophysiological status as measured by electroencephalogram (EEG) had a specificity of 94.7% and a sensitivity of 76.9% for predicting 1-week postoperative cognitive status and with specificity of 78.3% and a sensitivity of 77.8% for predicting 3-months postoperative cognitive status.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Postoperative Clinical Neurophysiological Assessment Open Heart Surgery

Interventions

Digital Electroencephalography (DEEG)DEVICE

The enrolled patients will undergo Digital Electroencephalography (DEEG) monitoring for at least two hours. A senior epileptologist will make a DEEG interpretation to detect DEEG abnormality. DEEG patterns will be categorized according to the American Clinical Neurophysiology Society's standardized critical care DEEG terminology(normal, slowing and asymmetry, sharp and wave, periodic discharges, ictal patterns burst suppression, and electrocerebral silence)

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient ≥ 60 years. * Both sexes. * Patients who are scheduled for on-pump open heart surgery either isolated coronary artery bypass grafting (CABG) or combined CABG and valve surgery. Exclusion Criteria: * Patients with a past history of CNS disease (e.g. Epilepsy, brain tumors, or Dementia). * Patients with metabolic disturbance. * Illiterate patient. * Patient with sever cognitive impairment on Mini-mental state Examination (MMSE) and/or Montreal Cognitive Assessment (MoCA) * Patients who cannot undergo DEEG recordings (eg, uncooperative). * Patients with abnormal brain images except for small vessel disease.

Locations (1)

Ain Shams University

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

Neurological complications

Neurological complications, including nonconvulsive seizures after open heart surgery, will be recorded.

Time frame: 4 months postoperatively

Secondary Outcomes

Electroencephalography (DEEG) monitoring

The enrolled patients will undergo Digital Electroencephalography (DEEG) monitoring for at least two hours. A senior epileptologist will interpret the DEEG to detect abnormalities. The DEEG patterns will be categorized according to the American Clinical Neurophysiology Society's standardized critical care DEEG terminology(normal, slowing and asymmetry, sharp and wave, periodic discharges, ictal patterns burst suppression, and electrocerebral silence).

Time frame: 24 hours postoperatively

Central Contacts

Osama A Ebrahim, Master

CONTACT

00201016386372 osamaallam@med.asu.edu.eg

Data from ClinicalTrials.gov

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