To Evaluate the Feasibility of Collecting Duodenal Fluid With SIMBA Capsules

Inclusion Criteria: * Age above 18 years * Written informed consent * Liver cirrhosis diagnosis by clinical/radiological/histological features * Able to swallow a size-00 capsule (23mm length and 8mm width) Exclusion Criteria: * Inability to give informed consent * Prior gastrointestinal disease, surgery, or radiation treatment which, in the Investigator's opinion, would lead to intestinal structuring or obstruction with a risk of capsule non-excretion, including, e.g., achalasia, eosinophilic esophagitis, cancer diagnosis or previous esophageal, gastric, small intestinal, or colonic surgery. Appendectomy or cholecystectomy more than 3 months before the screening visit is acceptable. * History of known structural gastrointestinal abnormalities such as structures or fistulas leading to mechanical obstruction. * Known history abdominal radiation treatment. * Use of any medications in the week prior to the screening study visit, unless part of regular treatment, that could substantially alter gastrointestinal motor function (e.g., opioids, prokinetics, anticholinergics, GLP-1 analogues); laxative use is allowed if it is kept unchanged in the week prior to the study visit. Proton pump inhibitors (PPIs) are allowed provided a wash-out period of 48 h before swallowing SIMBA capsules and PPI treatment is resumed only 4 hours thereafter. * Organic motility disorder, including gastroparesis, intestinal pseudo-obstruction, systemic sclerosis, Ogilvie's syndrome. * Any significant heart, liver, lung, kidney, blood, endocrine or nervous system disease, which in the opinion of the investigator, would adversely affect study safety or outcome. * History of oropharyngeal dysphagia, or other swallowing disorder with a risk of capsule aspiration. * Antibiotic use (except for topical use) ≤ 12 weeks prior to screening. Potential participants may be eligible once a 12-week washout is completed. * Consumption of probiotic or prebiotic supplements within 1 month prior to screening. Potential participants may be eligible once a 1-month washout is completed. * Any prior Fecal Microbiota Transplantation. * Colon cleanses/bowel prep for 2 weeks * Pregnant or breastfeeding. * Planning to become pregnant. * Are scheduled for an MRI at any time during the study. Potential participants may be eligible to participate once their MRI procedure is completed. * History of less than three (3) bowel movements per week.