The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery

Seoul National University Hospital190 enrolled

Overview

The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following cardiopulmonary bypass.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

190

Conditions

Acute Kidney Injury Pediatric Cardiac Surgery

Interventions

Albumin solutionDRUG

A 20% albumin solution is administered over one hour starting from the induction of anesthesia, using the following formula: (4.0-preoperative serum albumin (g/dL))×plasma volume (kg×0.65-0.8 dL)

Crystalloid solutionsDRUG

The same volume of crystalloid solution as the administered albumin is infused.

Eligibility

Sex: ALLMax age: 7 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pediatric patients under 7 years of age undergoing cardiac surgery with cardiopulmonary bypass * Preoperative serum albumin level of 4.0 g/dL or lower Exclusion Criteria: * abnormal preoperative creatinine level * history of dialysis * liver dysfunction * diabetes * history of hypersensitivity to albumin * coagulation disorders

Locations (1)

Seoul National University Hospital

Seoul, Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

incidence of acute kidney injury (AKI)

The difference in the incidence of acute kidney injury (AKI) between groups, as measured by the KDIGO criteria

Time frame: assessed up to postoperative day 7

Central Contacts

Ji-Hyun Lee

CONTACT

82-2-2072-3661 muslab6@snu.ac.kr

Data from ClinicalTrials.gov

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