Phototoxicity of Frequently Prescribed Medicines

Inclusion Criteria: 1. Written informed consent 2. Male or female 18-45 years of age (limits included) 3. BMI 19-27 for males and BMI 17-25 for females 4. Vital parameters at screening within normal limits 5. Electrocardiogram without clinically significant pathologic abnormalities and with QTc values lesser than 450 ms 6. Skin type II-IV on Fitzpatrick scale (table 1) 7. Women of childbearing potential agree to use adequate birth control methods during the entire study period. For all females, negative pregnancy test at screening and once monthly is required. Acceptable methods of contraception include: oral contraceptives, intrauterine device, female or male condoms with spermicide, diaphragm with spermicide, contraceptive medication patch, contraceptive medication implant, contraceptive medication injection, abstinence, or surgical sterilization more than 3 months before randomization. Exclusion Criteria: 1. Women known to be pregnant, lactating or having a positive or indeterminate pregnancy test 2. Lack of willingness or capacity to co-operate and comply with the study procedures appropriately 3. Failure to perform screening or baseline examinations 4. Regular use of any medication (prescription or over the counter) for prevention or treatment of any medical condition in the previous 2 months except intake of contraceptives 5. Intake of any medication throughout the active phase of the study that would interfere with the study procedure as per investigator's judgement 6. Use of dietary supplements in the previous 4 weeks, incl St. John's Wort 7. Exposure to UV-radiation (including direct or indirect sun exposure, solarium, phototherapy) or use of oral sun-protective substances and self-tanning products 2 weeks prior to first medication administration and during the entire study duration 8. Scars, previous trauma, tattoos or any other condition on the inner side of the arms that would impede the study procedures 9. Evidence of active infection requiring antibiotic therapy within 14 days prior to screening 10. Any chronic medical condition requiring chronic treatment, incl. liver disease, respiratory, cardiovascular or history of malignancies within the past two years or on current anticancer treatment 11. History of gastrointestinal pathology such as gastritis, gastric ulcers, irritable bowel disease, inflammatory bowel disease, chronic constipation 12. History of diarrhoea or emesis within the past 14 days of screening 13. History of gastrointestinal surgery with exception of appendectomy 14. History of chronic autoimmune disease incl. dermatitis requiring immunosuppressive treatment within the past two months of screening or any skin condition that induces photosensitivity 15. History of chronic skin disease potentially influencing the results (in particular skin diseases associated with photosensitivity) 16. History and/or family history of skin cancer, incl. but not limited to melanoma, basal cell carcinoma and squamous cell carcinoma. 17. Known symptomatic allergies, including food allergies or intolerances and sun allergy 18. Any clinically relevant laboratory abnormalities in screening test 19. Alcohol, cigarette or drug abuse 20. Mental condition rendering the subject unable to understand the nature, scope and possible consequences of the study 21. Presence of any condition that impacts compliance with the study procedures 22. Any underlying clinical condition that, in the opinion of the investigator, would make it very unlikely for the participant to complete the study successfully 23. Use of any investigational or non-registered product (drug or vaccine) within 30 days preceding the first study product administration, or planned use during the study period 24. Employee at the study site, spouse/partner or relative of any study staff (e.g. investigator, sub-investigators, or study nurse)