Effect of Povidone-iodine 5% Vs 1% on the Ocular Surface in Intravitreal Injections of Anti-VEGF

José Gerardo García Aguirre88 enrolled

Overview

Objective and subjective comparison between the use of povidone-iodine 1% vs 5% as antiseptic in patients that need anti-VEGF intravitreal injection

Randomized, prospective clinical trial. One group was intervened with povidone-iodine at 5% and the other at 1% as antiseptic for anti-VEGF intravitreal injection. Each patient was evaluated before and after the injection of anti-VEGF for tear break up time, bulbar redness and ocular surface satining with fluorescein. Pain perception was also evaluated 15 minutes after the injection and 48 hours after.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Dry Eye

Interventions

Change of normal concentration of povidone-iodine 5% to 1%PROCEDURE

Normal concentration of povidone-iodine during anti-VEGF intravitreal injection was 5%. That concentration was utilized in the control group, and 1% in the experimental group.

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria * Having anti-VGEF intravitreal injection scheduled * Informed consent signed Exclusion Criteria * Under 45 years * Opacity that prevents ophthalmological evaluation and fixation * Patients with severe dry eye * Patients with signs of infection on the ocular surface * Allergy to iodine * Pregnancy

Locations (1)

Asociación para Evitar la Ceguera en México I.A.P.

Mexico City, Mexico City, Mexico

Outcomes

Primary Outcomes

Tear breaking rupture

NIKBUT was measured with Keratopgraph before and after intravitreal injection

Time frame: Change from baseline measured to 15 minutes post-injection

Bulbar redness

Bulbar redness was measured with Keratopgraph before and after intravitreal injection

Time frame: Change from baseline measured to 15 minutes post-injection

Secondary Outcomes

Oxford scale

Oxford scale was measured with fluorescein stain before and after intravitreal injection

Time frame: Change from baseline measured to 15 minutes post-injection

Pain analog scale

Pain using visual analog scale was measured 15 minutes and 48 hours after intravitreal injection

Time frame: Change from baseline measured to 15 minutes post-injection

Data from ClinicalTrials.gov

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