Patients with senile cataracts undergoing phacoemulsification were assigned to receive intracameral levofloxacin (0.1ml/0.5mg) or intracameral cefazolin (0.1ml/1mg). The primary endpoint was the occurrence of endophthalmitis during the 3 month follow-up period. Secondary endpoints included best-corrected visual acuity (BVCA), the presence of anterior chamber (AC) inflammation with grading of AC cells and presence of flare, along with intraocular pressure (IOP), corneal cell thickness (CCT), central foveal thickness (CFT) and cell density.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
50
Intracameral levofloxacin (0.1ml/0.5mg)
Intracameral cefazolin (0.1ml/1mg)
Tan Tock Seng Hospital
Singapore, Singapore
Ang Mo Kio Specialist Center
Singapore, Singapore
Number of Participants with Treatment related adverse events to Intracameral Cefazolin versus Levofloxacin
Time frame: From cataract surgery through to study completion, an average of 1 year
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